Department of Neurology, the First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, China.
Department of Otolaryngology Head and Neck Surgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, 330006 Nanchang, Jiangxi, China.
J Integr Neurosci. 2022 Jun 28;21(4):120. doi: 10.31083/j.jin2104120.
To determine the influence of gender on the different pain subtypes experienced by patients with Parkinson's disease (PD).
Two hundred patients with PD were recruited for this research. Demographic features for all patients were recorded, as well as clinical data on age, disease duration, levodopa equivalent daily dose (LEDD), and scores for Unified Parkinson's Disease Rating Scale-III (UPDRS III), Hoehn-Yahr Scale (H&Y), King's Parkinson's disease Pain Scale (KPPS), Pittsburgh Sleep Quality Index (PSQI), Mini-mental State Examination (MMSE), activities of daily living scale (ADL), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) scales.
Male and female patients showed no significant differences in terms of age, disease duration, LEDD, H&Y stage, and UPDRS III, HAMD, HAMA, PSQI and ADL scores. Women showed significantly lower MMSE than men, but their KPPS scores were higher (both < 0.05). Female also showed significantly higher scores for chronic, fluctuation-related pain and oro-facial pain and more discoloration;edema/swelling than males ( < 0.05).
Female gender was associated with pain in PD patients, with stronger associations for certain subtypes of PD-related pain.
为了确定性别对帕金森病（PD）患者不同疼痛类型的影响。
本研究纳入了 200 名 PD 患者。记录所有患者的人口统计学特征，以及年龄、疾病持续时间、左旋多巴等效日剂量（LEDD）、统一帕金森病评定量表-III（UPDRS III）、Hoehn-Yahr 量表（H&Y）、帕金森病疼痛量表（KPPS）、匹兹堡睡眠质量指数（PSQI）、简易精神状态检查（MMSE）、日常生活活动量表（ADL）、汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）评分的临床数据。
男性和女性患者在年龄、疾病持续时间、LEDD、H&Y 分期和 UPDRS III、HAMD、HAMA、PSQI 和 ADL 评分方面无显著差异。女性的 MMSE 明显低于男性，但 KPPS 评分较高（均<0.05）。女性的慢性、波动相关疼痛和口腔面部疼痛以及更多变色、肿胀/水肿评分也明显高于男性（均<0.05）。
女性性别与 PD 患者的疼痛有关，与某些特定类型的 PD 相关疼痛的相关性更强。
