Grigorescu Andra, Dumitrescu Florentina, Dorobantu Stefania, Dragos Adina, Pirvu Andrei, Roskanovic Mihaela, Streata Ioana, Ioana Mihai, Netea Mihai G, Riza Anca-Lelia
Human Genomics Laboratory, Functional Genomics Group, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Medicina (Kaunas). 2025 Mar 26;61(4):596. doi: 10.3390/medicina61040596.
: Sepsis is one of the major causes of death in modern society. This study is part of the FUSE (Functional Genomics in Severe Sepsis) project under the Human Functional Genomics Romania initiative. Our aim was to assess the epidemiology of sepsis in a tertiary academic hospital in southwestern Romania. The study enrolled 184 patients with severe infections between May 2017 and November 2019, following the Sepsis-2 guidelines (SIRS criteria). The present cohort of community-acquired severe infections shows respiratory and urinary tract as main sites of severe infection. The demographic and clinical characteristics of this Romanian study group are in line with those of other severe infection European cohorts. However, the predominance of confirmed cases represents a strong deviation, raising significant concerns for the communities to which the patients belong. : Sepsis, with its complex pathophysiology and clinical presentation, remains one of the most daunting global health issues. In our cohort, the high number of cases prompts high vigilance and immediate intervention.
脓毒症是现代社会主要的死亡原因之一。本研究是罗马尼亚人类功能基因组计划下FUSE（严重脓毒症功能基因组学）项目的一部分。我们的目的是评估罗马尼亚西南部一家三级学术医院中脓毒症的流行病学情况。该研究在2017年5月至2019年11月期间，依据脓毒症-2指南（全身炎症反应综合征标准）纳入了184例严重感染患者。目前这一社区获得性严重感染队列显示，呼吸道和泌尿道是严重感染的主要部位。这个罗马尼亚研究组的人口统计学和临床特征与其他欧洲严重感染队列相符。然而，确诊病例的 predominance 代表了一个强烈偏差，引起了对患者所属社区的重大担忧。脓毒症因其复杂的病理生理学和临床表现，仍然是最令人生畏的全球健康问题之一。在我们的队列中，病例数量众多促使人们高度警惕并立即进行干预。 （注：原文中“predominance”未翻译完整，可能是录入有误，这里暂按原样呈现）
