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2021年和2022年格但斯克临时医院中感染SARS-CoV-2且伴有心血管疾病的患者的生存状况

The Conditions of Survival of Patients with a SARS-CoV-2 Infection Burdened by Cardiovascular Pathologies in a Temporary Hospital in Gdańsk in 2021 and 2022.

作者信息

Kostrzewa Dariusz, Milewska Anna Justyna, Iltchev Petre, Kaszubowski Mariusz, Dorobek Aleksandra, Marczak Michał, Rębas Elżbieta, Sierocka Aleksandra, Kozlowski Remigiusz

机构信息

Department of Management and Logistics in Healthcare, Medical University of Lodz, 90-419 Lodz, Poland.

Copernicus Podmiot Leczniczy Sp. z o.o., 80-803 Gdansk, Poland.

出版信息

J Clin Med. 2025 Apr 18;14(8):2806. doi: 10.3390/jcm14082806.

Abstract

A detailed analysis was carried out on the impact of cardiovascular disease on the risk of death of patients hospitalized at a temporary hospital in Gdańsk during the third and fifth waves of the COVID-19 pandemic (in 2021 and 2022, respectively). The documentation of 1244 patients was analyzed, of which 701 were hospitalized in 2021 (the Delta variant) and 543 in 2022 (the Omicron variant). The aim of this study was to assess the risk of death of patients with COVID-19 depending on the co-existence of cardiovascular diseases. A model of logistic regression was used to identify the impact of the patients' age, the coexistence of cardiovascular disease, and the length of hospitalization on the risk of death. In 2021, patients were younger (median of 66 years) than in 2022 (median of 74 years), the length of hospitalization was shorter in 2022 (9 days) than in 2021 (11 days), and there was a higher proportion of patients with cardiovascular and respiratory diseases and a medical history of cancer in 2022. The odds of death were also observed to be higher in older patients with cardiovascular disease, particularly those under 73 years of age. In older patients (over 73 years), the odds were paradoxically reduced. The age of the patient, cardiovascular disease, and duration of hospitalization affect the risk of death. The Delta variant (2021) was more virulent than Omicron (2022). Cardiovascular disease significantly increases the risk of death in patients with COVID-19. The comprehensive diagnosis and treatment of patients with these conditions may reduce mortality. Further studies are needed on the long-term effects of COVID-19 on the cardiovascular system.

摘要

对心血管疾病在新冠疫情第三波和第五波期间(分别为2021年和2022年)对格但斯克一家临时医院住院患者死亡风险的影响进行了详细分析。分析了1244例患者的病历,其中701例于2021年住院(德尔塔变种),543例于2022年住院(奥密克戎变种)。本研究的目的是评估合并心血管疾病的新冠患者的死亡风险。使用逻辑回归模型来确定患者年龄、心血管疾病合并情况以及住院时长对死亡风险的影响。2021年的患者比2022年的患者年轻(中位数分别为66岁和74岁),2022年的住院时长(9天)比2021年(11天)短,且2022年患有心血管和呼吸系统疾病以及有癌症病史的患者比例更高。还观察到患有心血管疾病的老年患者,尤其是73岁以下的患者,死亡几率更高。而在73岁以上的老年患者中,死亡几率反而降低。患者年龄、心血管疾病和住院时长会影响死亡风险。德尔塔变种(2021年)比奥密克戎变种(2022年)毒性更强。心血管疾病显著增加新冠患者的死亡风险。对这些患者进行综合诊断和治疗可能会降低死亡率。需要进一步研究新冠对心血管系统的长期影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d7e/12027972/7013d920aa47/jcm-14-02806-g0A1.jpg

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