Liu Peining, Yu Shuaishuai, Liu Jinrong, Zhou Yan, Cao Ruixue, Zhou Yonghai, Shi Linwei, Du Jimei
The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wenzhou Key Laboratory of Sanitary Microbiology, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Arch Med Sci. 2020 Sep 14;19(3):792-799. doi: 10.5114/aoms.2020.98927. eCollection 2023.
Hyperlipidemia refers to a group of lipid metabolism disorders characterized by increased levels of total cholesterol, triglyceride, and/or low-density lipoprotein cholesterol and/or decreased levels of high-density lipoprotein cholesterol. This study aims to investigate the effects of on lipid metabolism and hepatic steatosis in male mice fed with a high-fat diet by measuring blood lipid, hepatic function and hepatocyte morphology.
Eighty male Institute of Cancer Research (ICR) mice were fed with a high-fat diet for 6 weeks to establish hyperlipidemic models. Then, mice were treated with a high or low concentration of of human source, mouse source, or plant source, respectively.
After 3 weeks of therapy, except for the human treatment group, the blood cholesterol, triglyceride and low-density lipoprotein cholesterol in mice treated with of mouse and plant source were lower than those in the hyperlipidemic model group. After 4 weeks of treatment, the levels of blood biochemical indexes in mice in all treatment groups were significantly different, when compared to those in the hyperlipidemic model group.
may regulate blood lipid in mice fed with a high-fat diet. can improve the high cholesterol, high blood lipid, and injury of hepatic function, and prevent further development of atherosclerosis caused by a high-fat diet to some extent. Correct dietary structure is the basis for the treatment of dietary hyperlipidemia and its complications.
高脂血症是指一组脂质代谢紊乱，其特征为总胆固醇、甘油三酯和/或低密度脂蛋白胆固醇水平升高，和/或高密度脂蛋白胆固醇水平降低。本研究旨在通过测量血脂、肝功能和肝细胞形态，研究[未提及具体物质]对高脂饮食喂养的雄性小鼠脂质代谢和肝脂肪变性的影响。
80只雄性癌症研究所（ICR）小鼠用高脂饮食喂养6周以建立高脂血症模型。然后，小鼠分别用高浓度或低浓度的人源、鼠源或植物源[未提及具体物质]进行治疗。
治疗3周后，除人源[未提及具体物质]治疗组外，用鼠源和植物源[未提及具体物质]治疗的小鼠血液中的胆固醇、甘油三酯和低密度脂蛋白胆固醇低于高脂血症模型组。治疗4周后，与高脂血症模型组相比，所有治疗组小鼠的血液生化指标水平均有显著差异。
[未提及具体物质]可能调节高脂饮食喂养小鼠的血脂。[未提及具体物质]可改善高胆固醇、高血脂和肝功能损伤，并在一定程度上预防高脂饮食引起的动脉粥样硬化的进一步发展。正确的饮食结构是治疗饮食性高脂血症及其并发症的基础。
