Matheou Andreas, Abousetta Ayah, Pascoe Aphrodite Persephone, Papakostopoulos Demosthenis, Charalambous Loukas, Panagi Stelios, Panagiotou Stavros, Yiallouris Andreas, Filippou Charalampos, Johnson Elizabeth O
School of Medicine, European University Cyprus, Nicosia 2404, Cyprus.
School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Microorganisms. 2025 Mar 28;13(4):779. doi: 10.3390/microorganisms13040779.
Antimicrobial resistance (AMR) constitutes a pressing and intensifying global health crisis, significantly exacerbated by the inappropriate utilization and excessive application of antibiotics in livestock agriculture. The excessive use of antibiotics, including prophylactic and metaphylactic administration as well as growth-promotion applications, exacerbates selective pressures, fostering the proliferation of multidrug-resistant (MDR) bacterial strains. Pathogens such as , spp., and can be transmitted to humans through direct contact, contaminated food, and environmental pathways, establishing a clear link between livestock farming and human AMR outbreaks. These challenges are particularly pronounced in regions with limited veterinary oversight and weak regulatory frameworks. Addressing these issues requires the implementation of sustainable practices, enhanced antibiotic stewardship, and strengthened interdisciplinary collaboration. This review underscores the critical need for a One Health approach to mitigate AMR, recognizing the interconnectedness of human, animal, and environmental health in safeguarding global public health.
抗生素耐药性（AMR）构成了一场紧迫且日益严重的全球健康危机，畜牧业中抗生素的不当使用和过度应用极大地加剧了这一危机。抗生素的过度使用，包括预防性和治疗性给药以及促生长应用，加剧了选择压力，促使多重耐药（MDR）细菌菌株的增殖。诸如 、 属和 等病原体可通过直接接触、受污染的食物和环境途径传播给人类，在畜牧养殖与人类AMR疫情之间建立了明确的联系。这些挑战在兽医监管有限和监管框架薄弱的地区尤为突出。解决这些问题需要实施可持续做法、加强抗生素管理以及强化跨学科合作。本综述强调了采取“同一健康”方法来减轻AMR的迫切需求，认识到人类、动物和环境健康在保障全球公共卫生方面的相互关联性。
