Gutiérrez-Hurtado Itzae Adonai, Martínez-López Erika, Rico-Méndez Manuel Alejandro, Bravo-Villagra Karla Mayela, Mendoza-Jaramillo Héctor Eduardo, Sánchez-Rolón María Del Pilar, Betancourt-Núñez Alejandra, Gallegos-Arreola Martha Patricia, Tapia-Rivera José Carlos, López-Quintero Andres
Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Instituto de Nutrigenética y Nutrigenómica Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Viruses. 2025 Apr 10;17(4):552. doi: 10.3390/v17040552.
Human adenovirus 36 (HAdV-36) is associated with obesity, potentially by promoting adipocyte proliferation and differentiation. Although linked to increased fat storage, HAdV-36 is also correlated with improved insulin sensitivity. Given its potential role in modulating adipose tissue and promoting a less inflammatory metabolic profile, its impacts on pro- and anti-inflammatory cytokine secretion remain unclear.
This nested case-control study compared cytokine levels (IL-10, IL-2, IL-6, IL-8, and TNF-α) between patients with and without HAdV-36 infection. A total of 76 participants were included, with 37 in the control group (HAdV-36 negative) and 39 classified as cases (HAdV-36 positive).
HAdV-36 seropositive individuals exhibited significantly lower IL-6 levels and higher IL-8 levels than seronegative participants. Additionally, they had lower glucose levels, suggesting a potential link between HAdV-36 and metabolic regulation.
These findings support the hypothesis that HAdV-36 may influence inflammatory and metabolic responses by modulating cytokine expression and glucose levels. Further research is needed to clarify the underlying mechanisms and their implications for metabolic health.
人腺病毒36型（HAdV - 36）与肥胖有关，可能是通过促进脂肪细胞增殖和分化。尽管与脂肪储存增加有关，但HAdV - 36也与胰岛素敏感性改善相关。鉴于其在调节脂肪组织和促进炎症性较低的代谢谱方面的潜在作用，其对促炎和抗炎细胞因子分泌的影响仍不清楚。
这项巢式病例对照研究比较了感染和未感染HAdV - 36的患者之间的细胞因子水平（IL - 10、IL - 2、IL - 6、IL - 8和TNF -α）。总共纳入了76名参与者，其中37名在对照组（HAdV - 36阴性），39名被归类为病例组（HAdV - 36阳性）。
HAdV - 36血清阳性个体的IL - 6水平显著低于血清阴性参与者，而IL - 8水平更高。此外，他们的血糖水平较低，这表明HAdV - 36与代谢调节之间可能存在联系。
这些发现支持以下假设，即HAdV - 36可能通过调节细胞因子表达和血糖水平来影响炎症和代谢反应。需要进一步研究以阐明潜在机制及其对代谢健康的影响。
