Departamento de Ciencias Básicas para la Salud, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzmán 49000, Mexico.
Centro de Investigaciones Biomédicas, Universidad de Colima, Colima 28040, Mexico.
Viruses. 2023 Jul 7;15(7):1514. doi: 10.3390/v15071514.
Human adenovirus 36 (HAdV-36) has been associated with obesity and changes in glucose and lipid metabolism. The virus has been reported to increase insulin sensitivity and paradoxically promote weight gain. Because of its effects on metabolism, infection with the virus could alter the response to several drugs used to treat type 2 diabetes (DM2), such as metformin. The aim of this study was to test whether HAdV-36 affects the response to metformin in a group of obese patients with DM2.
In a prospective cohort study, 103 obese patients with newly diagnosed DM2 were divided into two groups based on their HAdV-36 seropositivity (+HAdV-36 and -HAdV-36). Weight, glucose, cholesterol, triglycerides, body mass index, body fat percentage, and waist and hip circumference were measured and compared in both groups at baseline and after 45 days of metformin treatment.
Only glucose was significantly lower in the +HAdV-36 group at baseline, while all other variables were similar between the two study groups. After 45 days of follow-up, it was observed that the effect of metformin did not differ between the groups, but the variables improved significantly after treatment.
In this study, we did not find that HAdV-36 had an effect on the response to metformin in obese patients with DM2.
人类腺病毒 36（HAdV-36）与肥胖以及葡萄糖和脂质代谢变化有关。有报道称，该病毒会增加胰岛素敏感性，并且矛盾的是会促进体重增加。由于其对新陈代谢的影响，感染该病毒可能会改变几种用于治疗 2 型糖尿病（DM2）的药物的反应，例如二甲双胍。本研究旨在测试 HAdV-36 是否会影响一组肥胖的 DM2 患者对二甲双胍的反应。
在一项前瞻性队列研究中，根据 HAdV-36 血清阳性（+HAdV-36 和 -HAdV-36）将 103 例新诊断为 DM2 的肥胖患者分为两组。在基线和接受 45 天二甲双胍治疗后，测量并比较两组患者的体重、血糖、胆固醇、甘油三酯、体重指数、体脂百分比以及腰围和臀围。
仅在基线时，+HAdV-36 组的血糖明显较低，而两组之间的其他变量相似。经过 45 天的随访，观察到两组之间二甲双胍的作用没有差异，但是治疗后所有变量均明显改善。
在这项研究中，我们没有发现 HAdV-36 对肥胖的 DM2 患者对二甲双胍的反应有影响。
