Gao Shuang, Yan Honglei, Xiu Yue, Li Fengrui, Zhang Yu, Wang Ruichi, Zhao Lixia, Ye Fei, Fu Ying
Department of Chemistry, Northeast Agricultural University, Harbin 150030, China.
Molecules. 2025 Mar 25;30(7):1456. doi: 10.3390/molecules30071456.
The discovery of efficient and stable nanopesticides with improved water solubility and sustained release effects has become particularly important. Pyrimethanil (Pyr) as a low toxicity fungicide of an aniline pyrimidine group is widely used for the prevention and control of gray mold in crops and ornamental plants, however, poor water solubility hinders its further development. Herein, we use a supramolecular self-assembly process to encapsulate a pyrimethanil in a hydroxypropyl-gamma-cyclodextrin (HPγCD) via electrostatic interactions, thereby constructing the inclusion complex nanofibers. The HPγCD as an environmentally friendly carrier material for pesticide delivery is favorable for facilitating the control efficacy, water solubility, and thermostability with Pyr. The diameter of the prepared inclusion nanofiber is 426.6 ± 82.1 nm. Pyr/HPγCD inclusion complex nanofibers could be completely dissolved in water within 3 s. As predicted, the fungicidal activity of Pyr/HPγCD inclusion complex nanofibers is much higher than that of either Pyr, and the EC value of Pyr/HPγCD inclusion nanofibers is 0.437 μg/mL, which is about half of that of Pyr (0.840 μg/mL). The inclusion strategy achieved by Pyr and HPγCD is important for improving the safety of nanopesticides. This work provides a versatile insight to promote the development of water-based pesticide dosage forms and reduce pesticide losses in agricultural production.
发现具有高效、稳定、改善的水溶性和缓释效果的纳米农药变得尤为重要。嘧霉胺（Pyr）作为一种苯胺嘧啶类低毒杀菌剂，广泛用于防治农作物和观赏植物中的灰霉病，然而，其水溶性差阻碍了它的进一步发展。在此，我们利用超分子自组装过程通过静电相互作用将嘧霉胺包裹在羟丙基-γ-环糊精（HPγCD）中，从而构建包合物纳米纤维。HPγCD作为一种用于农药递送的环保载体材料，有利于提高与嘧霉胺相关的防治效果、水溶性和热稳定性。制备的包合物纳米纤维直径为426.6±82.1nm。Pyr/HPγCD包合物纳米纤维能在3秒内完全溶解于水中。正如预测的那样，Pyr/HPγCD包合物纳米纤维的杀菌活性远高于单独的Pyr，Pyr/HPγCD包合物纳米纤维的EC值为0.437μg/mL，约为Pyr（0.840μg/mL）的一半。由Pyr和HPγCD实现的包合策略对于提高纳米农药的安全性很重要。这项工作为促进水基农药剂型的发展和减少农业生产中的农药损失提供了一个全面的视角。
