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具有过氧化物酶模拟活性的基于锰酞菁的磁性核壳复合材料用于比色法检测抗坏血酸和谷胱甘肽

Manganese Phthalocyanine-Based Magnetic Core-Shell Composites with Peroxidase Mimetic Activity for Colorimetric Detection of Ascorbic Acid and Glutathione.

作者信息

Qi Junchao, Tian Long, Pang Yudong, Wu Fengshou

机构信息

Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Key Laboratory of Novel Biomass-Based Environmental and Energy Materials in Petroleum and Chemical Industry, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430072, China.

出版信息

Molecules. 2025 Mar 27;30(7):1484. doi: 10.3390/molecules30071484.

DOI:10.3390/molecules30071484
PMID:40286109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11990450/
Abstract

Ascorbic acid (AA) and glutathione (GSH) play a pivotal role in health assessment, drug development, and quality control of nutritional supplements. The development of a new and efficient method for their detection is highly desired. In this work, we fabricated magnetic core-shell nanocomposites (FeO@MnPc-NDs) by a one-pot hydrothermal method with citric acid and manganese tetraamino phthalocyanine (MnTAPc) as precursors. FeO@MnPc-NDs exhibited enhanced peroxidase activity compared to bare FeO nanoparticles, enabling catalytic oxidation of colorless 3,3',5,5'-tetramethylbenzidine (TMB) to blue ox-TMB in the presence of HO. Leveraging the antioxidant properties of AA/GSH to reduce ox-TMB, a colorimetric assay achieved a low detection limit of 0.161 μM for AA and 0.188 μM for GSH with broad linear ranges. Moreover, this method displayed high specificity against 12 interfering substances and excellent recyclability (>90% activity after five cycles). Finally, the FeO@MnPc-NDs could act as an efficient colorimetric sensor for accurately detecting AA in genuine VC tablets and GSH in whitening serums with high accuracy. Therefore, FeO@MnPc-NDs exhibited great potential in bioassay applications, benefiting from their outstanding sensitivity and high recycling rate.

摘要

抗坏血酸（AA）和谷胱甘肽（GSH）在健康评估、药物开发以及营养补充剂的质量控制中发挥着关键作用。因此，迫切需要开发一种新的高效检测方法。在本研究中，我们以柠檬酸和四氨基锰酞菁（MnTAPc）为前驱体，通过一锅水热法制备了磁性核壳纳米复合材料（FeO@MnPc-NDs）。与裸FeO纳米颗粒相比，FeO@MnPc-NDs表现出增强的过氧化物酶活性，能够在HO存在的情况下将无色的3,3',5,5'-四甲基联苯胺（TMB）催化氧化为蓝色的氧化型TMB（ox-TMB）。利用AA/GSH的抗氧化特性来还原ox-TMB，建立了一种比色法，对AA的检测限低至0.161 μM，对GSH的检测限低至0.188 μM，且线性范围宽。此外，该方法对12种干扰物质具有高特异性，并且具有出色的可回收性（五个循环后活性>90%）。最后，FeO@MnPc-NDs可以作为一种高效的比色传感器，用于准确检测正品维生素C片中的AA和美白血清中的GSH。因此，FeO@MnPc-NDs凭借其出色的灵敏度和高回收率在生物测定应用中展现出巨大潜力。

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