Naeser M A, Helm-Estabrooks N
Cortex. 1985 Jun;21(2):203-23. doi: 10.1016/s0010-9452(85)80027-7.
The purpose of this retrospective study was to investigate the relationship between CT scan lesion localization and good or poor response to Melodic Intonation Therapy (MIT) as measured by pre- and post-MIT treatment scores. The four good response (GR) cases improved in speech characteristics ratings for Phrase Length and Grammatical Form on the Boston Diagnostic Aphasia Examination; the four poor response (PR) cases showed no improvement. The GR cases had lesions which involved Broca's area and/or white matter deep to it plus large superior lesion extension into periventricular white matter deep to the lower motor cortex area for face. These GR cases had no large lesion in Wernicke's area and no lesion in the temporal isthmus or the right hemisphere. The PR cases, however, had bi-lateral lesions or lesion including Wernicke's area or the temporal isthmus.
这项回顾性研究的目的是调查CT扫描病变定位与旋律语调疗法（MIT）治疗前后评分所衡量的对该疗法反应良好或不佳之间的关系。4例反应良好（GR）的病例在波士顿诊断性失语症检查中，短语长度和语法形式的言语特征评分有所改善；4例反应不佳（PR）的病例则无改善。GR病例的病变累及布洛卡区和/或其深部白质，加上较大的上部分病变延伸至面部下运动皮层区域深部的脑室周围白质。这些GR病例在韦尼克区没有大的病变，在颞峡或右半球也没有病变。然而，PR病例有双侧病变或包括韦尼克区或颞峡的病变。
