García-Casares Natalia, Barros-Cano Amanda, García-Arnés Juan A
School of Medicine, University of Málaga, 29010 Málaga, Spain.
Unidad de Neurología Clínica, Centro de Investigaciones Médico-Sanitarias (CIMES), Campus de Teatinos, University of Málaga, 29010 Málaga, Spain.
J Clin Med. 2022 Jun 17;11(12):3503. doi: 10.3390/jcm11123503.
Melodic Intonation Therapy (MIT) is one of the most well-known therapies for the rehabilitation of speech in patients with non-fluent aphasia and which is thought to promote right-hemisphere involvement in language processing. This review focuses on the study of language lateralization and/or neuroplastic reorganization with neuroimaging and/or neurophysiological techniques in non-fluent aphasic patients post-stroke during or after MIT. A systematic search was carried out according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) in databases (PubMed, Scopus, EMBASE, Dialnet, Web of Science, Cochrane) with the keywords melodic intonation therapy, neuroimaging, functional magnetic resonance, and positron emission tomography and the boolean operators AND and OR. Articles including patients of all ages and either sex with any type of aphasia post-stroke and in any language, which studied language lateralization and/or neuroplastic reorganization after or during MIT were included. Articles which did not achieve the objectives, revisions and conferences were excluded. Different results were obtained from the 16 studies included in the review: predominantly greater activation of the right hemisphere but also of the left hemisphere or both. MIT is an effective therapy to rehabilitate non-fluent aphasic patients post-stroke. It involves different neurobiological mechanisms and depends on multiple individual factors. Studies with larger samples are necessary.
旋律语调疗法（MIT）是治疗非流畅性失语患者言语康复最著名的疗法之一，被认为能促进右半球参与语言处理。本综述聚焦于运用神经影像学和/或神经生理学技术，对非流畅性失语中风患者在接受MIT期间或之后的语言侧化和/或神经可塑性重组进行研究。根据系统评价和Meta分析的首选报告项目（PRISMA），在数据库（PubMed、Scopus、EMBASE、Dialnet、科学网、Cochrane）中进行了系统检索，关键词为旋律语调疗法、神经影像学、功能磁共振成像和正电子发射断层扫描以及布尔运算符AND和OR。纳入的文章涵盖所有年龄和性别的中风后失语患者，语言不限，研究了MIT之后或期间的语言侧化和/或神经可塑性重组。未达到目标的文章、综述和会议文献被排除。从纳入综述的16项研究中获得了不同的结果：主要是右半球激活增强，但也有左半球或双侧半球激活增强。MIT是一种有效的中风后非流畅性失语患者康复疗法。它涉及不同的神经生物学机制，且取决于多个个体因素。有必要开展更大样本量的研究。
