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From bench to bedside: the future of stable lentiviral packaging cell lines in gene therapy.

作者信息

Theva Das Kumitaa

机构信息

Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Gelugor, Penang, Malaysia.

出版信息

Gene Ther. 2025 Apr 26. doi: 10.1038/s41434-025-00537-6.

DOI:10.1038/s41434-025-00537-6

PMID:40287519

Abstract

摘要

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From bench to bedside: the future of stable lentiviral packaging cell lines in gene therapy.

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本文引用的文献

Target product profile for cell-based and gene-based therapies to achieve a cure for HIV.

Lancet HIV. 2025 Feb;12(2):e154-e162. doi: 10.1016/S2352-3018(24)00277-7. Epub 2025 Jan 3.

A new frontier: FDA approvals for gene therapy in sickle cell disease.

Mol Ther. 2024 Feb 7;32(2):264-267. doi: 10.1016/j.ymthe.2024.01.015. Epub 2024 Jan 20.

CASGEVY Makes History as FDA Approves First CRISPR/Cas9 Genome Edited Therapy.

Hum Gene Ther. 2024 Jan;35(1-2):1-4. doi: 10.1089/hum.2023.29263.bfs.

Viral vector platforms within the gene therapy landscape.

Signal Transduct Target Ther. 2021 Feb 8;6(1):53. doi: 10.1038/s41392-021-00487-6.

LentiPro26: novel stable cell lines for constitutive lentiviral vector production.

Sci Rep. 2018 Mar 27;8(1):5271. doi: 10.1038/s41598-018-23593-y.

Production of lentiviral vectors.

Mol Ther Methods Clin Dev. 2016 Apr 13;3:16017. doi: 10.1038/mtm.2016.17. eCollection 2016.

Construction of stable packaging cell lines for clinical lentiviral vector production.

Sci Rep. 2015 Mar 12;5:9021. doi: 10.1038/srep09021.

Inducible packaging cells for large-scale production of lentiviral vectors in serum-free suspension culture.

Mol Ther. 2008 Mar;16(3):500-7. doi: 10.1038/sj.mt.6300383. Epub 2008 Jan 8.

How not to be seen: immune-evasion strategies in gene therapy.

Gene Ther. 2008 Feb;15(4):239-46. doi: 10.1038/sj.gt.3303082. Epub 2007 Nov 29.

A new-generation stable inducible packaging cell line for lentiviral vectors.

Hum Gene Ther. 2001 May 20;12(8):981-97. doi: 10.1089/104303401750195935.

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From bench to bedside: the future of stable lentiviral packaging cell lines in gene therapy.

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