Zhou Tai-Zeng, Chen Qiu-Yang, Yang Yi-Ting, Gan Mai-Lin, Zhu Li, Shen Lin-Yuan
National Key Laboratory of Pig and Poultry Seed Industry, Sichuan Agricultural University, Chengdu 611130, China.
Sichuan Provincial Key Laboratory of Exploration and Innovative Utilization of Livestock and Poultry Genetic Resources, Sichuan Agricultural University, Chengdu 611130, China.
Yi Chuan. 2025 May;47(5):513-532. doi: 10.16288/j.yczz.24-252.
MicroRNA (miRNA) is a class of single-stranded non-coding short RNA molecules about the size of 22 nt. Currently, miRNA has received the most extensive research and attention, and miRNA has been shown to be involved in the post-transcriptional regulation of gene expression in almost all cellular events, including cell proliferation, migration, differentiation, and apoptosis. miRNA plays an important role in the process of muscle regeneration by targeting key factors at different stages of skeletal muscle regeneration. In this review, we summarize the role of miRNA in regulating muscle regeneration by affecting satellite cell quiescence, myoblast proliferation, and differentiation during muscle regeneration, and update the relationship between miRNA and PI3K/AKT, TGF-β/Smad signaling during muscle regeneration. The research progress of pathway interaction will help researchers to learn more about the knowledge of miRNA in muscle regeneration biology, and provide a better understanding of the involvement of non-coding RNAs in muscle regeneration.
微小RNA（miRNA）是一类单链非编码短RNA分子，大小约为22个核苷酸。目前，miRNA受到了最广泛的研究和关注，并且已表明miRNA几乎参与了所有细胞活动中的基因表达的转录后调控，包括细胞增殖、迁移、分化和凋亡。miRNA通过靶向骨骼肌再生不同阶段的关键因子，在肌肉再生过程中发挥重要作用。在本综述中，我们总结了miRNA在肌肉再生过程中通过影响卫星细胞静止、成肌细胞增殖和分化来调节肌肉再生的作用，并更新了miRNA与肌肉再生过程中PI3K/AKT、TGF-β/Smad信号传导之间的关系。通路相互作用的研究进展将有助于研究人员更多地了解miRNA在肌肉再生生物学中的知识，并更好地理解非编码RNA在肌肉再生中的作用。
