Zhang Xueling, Zhang Yongxin, Wang Ting, Xiao Deng, Wang Jianding, Ma Chao, Liu Tong, Zhao Duoming, Li Sheng, Wang Junling, Li Chengyun
Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, 730000, China.
Qinghai Center for Disease Control and Prevention, Qinghai, 810000, China.
Biol Trace Elem Res. 2025 Apr 27. doi: 10.1007/s12011-025-04637-7.
Cadmium (Cd) is a major environmental pollutant associated with male reproductive health. Lycium barbarum polysaccharides (LBP) and selenium (Se) have been shown to protect against testicular damage. Male rats (180-200 g) were selected to construct a Cd-exposed model by intraperitoneal injection with concentrations of 0.0, 0.5, 1.0, 1.5, and 2.0 mg/kg. Then, LBP and sodium selenite (NaSeO) were given by gavage for treatment. The results showed that Cd accumulates in the testis in a dose-dependent manner, and compared with the control group, after Cd-exposed, the testis suffered significant toxic damage. The differences in mRNA enrichment analysis between the Cd-exposed and the control groups showed that the differential genes were mainly involved in peroxidase activity, iron regulation, and cellular energy metabolism. Compared with the Cd-exposed group, LBP and NaSeO intervention could antagonize the toxic damaging effects caused by Cd, and the combined intervention of LBP and NaSeO could better antagonize the toxic damaging effects caused by Cd compared with the intervention alone. In general, Cd exposure caused testicular damage, increased testicular hormonal disorders, oxidative stress damage, energy metabolism disorders, and iron atrophy in the testis, while treatment with LBP and selenium alleviated the effects of Cd-induced testicular toxicity damage.
镉（Cd）是一种与男性生殖健康相关的主要环境污染物。枸杞多糖（LBP）和硒（Se）已被证明可预防睾丸损伤。选用雄性大鼠（180 - 200克），通过腹腔注射浓度为0.0、0.5、1.0、1.5和2.0毫克/千克的镉来构建镉暴露模型。然后，通过灌胃给予LBP和亚硒酸钠（NaSeO）进行治疗。结果表明，镉以剂量依赖的方式在睾丸中蓄积，与对照组相比，镉暴露后睾丸遭受了显著的毒性损伤。镉暴露组与对照组之间的mRNA富集分析差异表明，差异基因主要参与过氧化物酶活性、铁调节和细胞能量代谢。与镉暴露组相比，LBP和NaSeO干预可拮抗镉引起的毒性损伤作用，且LBP和NaSeO联合干预比单独干预能更好地拮抗镉引起的毒性损伤作用。总体而言，镉暴露导致睾丸损伤，增加睾丸激素紊乱、氧化应激损伤、能量代谢紊乱以及睾丸中铁萎缩，而LBP和硒治疗可减轻镉诱导的睾丸毒性损伤的影响。
