Rodriguez Violeta J, Gessert Miranda, Guerra Arianna
Department of Psychology, University of Illinois Urbana Champaign, Champaign, USA.
AIDS Behav. 2025 Apr 28. doi: 10.1007/s10461-025-04721-y.
HIV poses a significant issue in the United States and understanding how HIV-positive populations adhere to treatments, specifically with antiretroviral therapy (ART), is vital for researchers to find approaches to improve medication adherence. This systematic review aims to explore barriers that children, adolescents, and young people (ages < 25) in the United States may face by exploring family interventions and factors influencing ART adherence. This study conducted a literature search using various databases to retrieve studies within the United States. A total of 36 studies identified family factors (n = 29) and various interventions (n = 7). Across both categories, studies indicated the critical role of family involvement in adherence outcomes. The review also identified significant barriers to ART adherence, including complex medication regimens, HIV-related stigma, and psychosocial stressors. Due to the diverse barriers, policymakers and healthcare providers should focus on a holistic approach to support ART adherence in HIV-positive youth.
在美国，艾滋病病毒（HIV）是一个重大问题，了解HIV阳性人群如何坚持治疗，特别是抗逆转录病毒疗法（ART），对于研究人员寻找提高药物依从性的方法至关重要。本系统综述旨在通过探索家庭干预措施以及影响ART依从性的因素，来探究美国儿童、青少年和年轻人（年龄<25岁）可能面临的障碍。本研究使用多个数据库进行文献检索，以获取美国境内的研究。总共识别出36项研究，其中涉及家庭因素的有29项，各种干预措施的有7项。在这两类研究中，均表明家庭参与对依从性结果起着关键作用。该综述还确定了ART依从性的重大障碍，包括复杂的药物治疗方案、与HIV相关的耻辱感以及心理社会压力源。由于存在多种障碍，政策制定者和医疗服务提供者应注重采用整体方法来支持HIV阳性青年坚持ART治疗。
