Wood R A, Baker A L, Hall A W, Boyer J L, Moossa A R
Ann Surg. 1977 Mar;185(3):349-55. doi: 10.1097/00000658-197703000-00017.
An unchaired monkey model for the repeated long-term study of biliary secretory physiology is reported. Postoperative management with cholre recorded. Evaluation was performed by repeated measurement, over a period of months, of bile flow and 14C erythritol clearance at three rates of taurocholate infusion given intravenously in a random order. Response to secretin was tested at the final infusion rate of taurocholate for each experiment. The outcomes of 9 monkeys were described of which 5 were repeatedly studied. They demonstrated an increase in bile flow and 14C erythritol clearance with increasing bile salt output. A dramatic choleresis over a wide range of bile salt excretion was noted with secretin and a linear relationship between bile bicarbonate output and bile salt secretion rate was observed. The new model has several major advantages and gives higher bile flows than previously recorded in the chaired model.
本文报道了一种用于长期重复研究胆汁分泌生理学的无椅式猴子模型。记录了术后胆汁分泌情况。通过在几个月的时间里，以随机顺序静脉内给予三种牛磺胆酸盐输注速率，重复测量胆汁流量和14C赤藓糖醇清除率来进行评估。在每个实验中，以牛磺胆酸盐的最终输注速率测试对促胰液素的反应。描述了9只猴子的实验结果，其中5只进行了重复研究。结果表明，随着胆盐输出量的增加，胆汁流量和14C赤藓糖醇清除率增加。观察到促胰液素在广泛的胆盐排泄范围内引起显著的利胆作用，并且观察到胆汁碳酸氢盐输出与胆盐分泌速率之间存在线性关系。新模型有几个主要优点，并且产生的胆汁流量比之前有椅式模型记录的更高。
