Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.
Clin Gastroenterol Hepatol. 2024 Sep;22(9):1947-1949.e3. doi: 10.1016/j.cgh.2024.02.011. Epub 2024 Feb 29.
Alcohol is a substance that impacts premature mortality and morbidity. The liver is invariably subjected to the impact of alcohol, which can result in cirrhosis and cancer. Alcohol also has detrimental effects that extend beyond the liver. While traditionally associated with advanced age, emerging data reported a rising burden of cancers and alcohol-associated liver disease in the young. Thus, the primary objective was to evaluate the trend of alcohol-associated cirrhosis and cancer in young and middle-aged adults (aged 15-49) utilizing the Global Burden of Disease Study (GBD) 2019. We chose the age group less than 50 years old based on the definition of early-onset cancer and the inherent selection of the age group in the GBD database. The detailed methods are provided in the Supplementary Appendix. Briefly, data were sourced from population-based cancer registries, vital registration systems, or verbal autopsy studies. Verbal autopsy is a well-established approach for monitoring health, providing valuable information on mortality patterns and the reasons behind deaths in areas lacking robust medical death certification processes. The researchers employed the Cause of Death Ensemble model to estimate the burden linked to cancer and cirrhosis associated with alcohol use.
酒精是一种会影响早逝和发病的物质。肝脏总是受到酒精的影响，这可能导致肝硬化和癌症。酒精的影响还不止于此。尽管传统上与老年有关，但新出现的数据报告称，年轻人的癌症和酒精性肝病负担正在增加。因此，我们的主要目的是利用全球疾病负担研究（GBD）2019 评估 15-49 岁的年轻人和中年人中与酒精相关的肝硬化和癌症的趋势。我们选择年龄小于 50 岁的人群，这是基于早发性癌症的定义和 GBD 数据库中该年龄组的固有选择。详细方法见附录。简而言之，数据来自基于人群的癌症登记处、生命登记系统或死因推断研究。死因推断是一种成熟的监测健康的方法，它为缺乏可靠医疗死亡认证程序的地区的死亡率模式和死亡原因提供了有价值的信息。研究人员使用死因综合模型来估计与癌症和肝硬化相关的与酒精使用有关的负担。
