Schaffner F, Dienstag J L, Purcell R H, Popper H
Arch Pathol Lab Med. 1977 Mar;101(3):113-7.
Electron microscopical studies were carried out on coded liver biopsy specimens from chimpanzees inoculated with human hepatitis A or B virus. Hepatitis B was recognized by the presence of hepatitis B core particles in hepatocellular nuclei. Hepatitis A was characterized by unidentified large, dense, and more irregular heterochromatin-like particles in hepatocellular nuclei coincidental with peak aminotransferase activities. As type A hepatitis illness became manifest in the chimpanzees, mitochondrial cristae were curled and attenuated, and clusters of endoplasmic reticulum were tightly packed. In contrast, the livers in viral hepatitis B showed mainly hypertrophy of tubular smooth endoplasmic reticulum. This suggested different pathogenetic mechanisms in A and B chimpanzee viral hepatitis.
对接种人甲型或乙型肝炎病毒的黑猩猩的肝脏活检标本进行了电子显微镜研究。乙型肝炎通过在肝细胞核中存在乙型肝炎核心颗粒来识别。甲型肝炎的特征是在肝细胞核中出现不明的大的、致密的且更不规则的异染色质样颗粒，同时伴有转氨酶活性峰值。随着甲型肝炎在黑猩猩中显现，线粒体嵴卷曲且变细，内质网簇紧密堆积。相比之下，乙型病毒性肝炎的肝脏主要表现为管状滑面内质网肥大。这表明甲型和乙型黑猩猩病毒性肝炎的发病机制不同。
