Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas 782227.
Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital and College of Medicine, The Ohio State University, Columbus, Ohio 43205.
Cold Spring Harb Perspect Med. 2019 Feb 1;9(2):a031815. doi: 10.1101/cshperspect.a031815.
Although phylogenetically unrelated, human hepatitis viruses share an exclusive or near exclusive tropism for replication in differentiated hepatocytes. This narrow tissue tropism may contribute to the restriction of the host ranges of these viruses to relatively few host species, mostly nonhuman primates. Nonhuman primate models thus figure prominently in our current understanding of the replication and pathogenesis of these viruses, including the enterically transmitted hepatitis A virus (HAV) and hepatitis E virus (HEV), and have also played major roles in vaccine development. This review draws comparisons of HAV and HEV infection from studies conducted in nonhuman primates, and describes how such studies have contributed to our current understanding of the biology of these viruses.
虽然在系统发生上没有关系，但人类肝炎病毒在分化的肝细胞中具有独特或近乎独特的复制倾向性。这种狭窄的组织嗜性可能导致这些病毒的宿主范围局限于少数宿主物种，主要是非人类灵长类动物。因此，非人类灵长类动物模型在我们目前对这些病毒的复制和发病机制的理解中起着重要作用，包括肠道传播的甲型肝炎病毒（HAV）和戊型肝炎病毒（HEV），并且在疫苗开发中也发挥了重要作用。这篇综述通过在非人类灵长类动物中进行的研究比较了 HAV 和 HEV 的感染，并描述了这些研究如何促进我们对这些病毒生物学的现有理解。
