Oliver Zachary J, Abrams Dylan J, Cardinale Luana, Chen Chih-Jung, Beutner Gregory L, Caille Seb, Cohen Benjamin, Deng Lin, Diwan Moiz, Frederick Michael O, Harper Kaid, Hawkins Joel M, Lehnherr Dan, Lucky Christine, Meyer Alex, Noh Seonmyeong, Nunez Diego, Quasdorf Kyle, Teli Jaykumar, Stahl Shannon S, Schreier Marcel
Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
ACS Cent Sci. 2025 Feb 11;11(4):528-538. doi: 10.1021/acscentsci.4c01733. eCollection 2025 Apr 23.
Organic electrosynthesis opens new avenues of reactivity and promises more sustainable practices in the preparation of fine chemicals and pharmaceuticals. The full value of this approach will be realized by taking these processes to the production scale; however, achieving this goal will require a better understanding of the influence of mass transport on reaction behavior and the interactions between reactive species and electrodes inherent to organic electrosynthesis. The limited options for cell geometries used on small scale limit elucidation of these features. Here, we show how advanced cell geometries allow us to control the interplay between reaction mechanism and mass transport, leading to improved performance of three modern organic electrosynthetic reactions. Each reaction shows a unique relationship with mass transport, highlighting the importance of understanding this relationship further to maximize the utility of organic electrosynthesis at scale.
有机电合成开辟了新的反应途径，并有望在精细化学品和药物的制备中实现更可持续的方法。要实现这种方法的全部价值，需要将这些过程扩大到生产规模；然而，要实现这一目标，需要更好地理解传质对反应行为的影响以及有机电合成中活性物种与电极之间的相互作用。小规模使用的电池几何形状选择有限，限制了对这些特征的阐明。在这里，我们展示了先进的电池几何形状如何使我们能够控制反应机理与传质之间的相互作用，从而提高三种现代有机电合成反应的性能。每个反应都显示出与传质的独特关系，突出了进一步理解这种关系对于在规模上最大化有机电合成效用的重要性。
