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尿液培养中的抗抑郁药与抗生素耐药性：一项队列研究。

Antidepressants and antibiotic resistance in urine cultures: a cohort study.

作者信息

Sears Isaac, Davis Michel, Gibas Kevin, Mermel Leonard, Heffernan Daithi S

机构信息

The Warren Alpert Medical School of Brown University, Providence, RI, USA.

Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA.

出版信息

Antimicrob Steward Healthc Epidemiol. 2025 Apr 23;5(1):e98. doi: 10.1017/ash.2025.73. eCollection 2025.

DOI:10.1017/ash.2025.73
PMID:40290183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12022929/
Abstract

evidence of antidepressant-driven antibiotic resistance has recently been described. In this retrospective cohort study, significant associations are identified between antidepressant use and antibiotic resistance on urine cultures taken in the Emergency Department. This epidemiologic data supports previous  work and raises additional questions for further study.

摘要

最近有关于抗抑郁药导致抗生素耐药性的证据被描述。在这项回顾性队列研究中，在急诊科采集的尿培养样本中，发现抗抑郁药的使用与抗生素耐药性之间存在显著关联。这一流行病学数据支持了之前的研究工作，并提出了更多有待进一步研究的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c444/12022929/ff8fd3a56a94/S2732494X25000737_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c444/12022929/ff8fd3a56a94/S2732494X25000737_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c444/12022929/ff8fd3a56a94/S2732494X25000737_fig1.jpg

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本文引用的文献

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Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation.抗抑郁药通过转化作用促进细胞外抗生素耐药基因的传播。
ISME Commun. 2022 Jul 28;2(1):63. doi: 10.1038/s43705-022-00147-y.
2
Antimicrobial activity of antidepressants on normal gut microbiota: Results of the study.抗抑郁药对正常肠道微生物群的抗菌活性：研究结果
Front Behav Neurosci. 2023 Mar 22;17:1132127. doi: 10.3389/fnbeh.2023.1132127. eCollection 2023.
3
Antidepressants can induce mutation and enhance persistence toward multiple antibiotics.
抗抑郁药可诱导突变并增强对多种抗生素的持久性。
Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2208344120. doi: 10.1073/pnas.2208344120. Epub 2023 Jan 23.
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MIMIC-IV, a freely accessible electronic health record dataset.MIMIC-IV，一个可自由访问的电子健康记录数据集。
Sci Data. 2023 Jan 3;10(1):1. doi: 10.1038/s41597-022-01899-x.
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TCA and SSRI Antidepressants Exert Selection Pressure for Efflux-Dependent Antibiotic Resistance Mechanisms in Escherichia coli.三氯乙酸和 SSRI 类抗抑郁药对大肠杆菌中依赖外排的抗生素耐药机制施加选择压力。
mBio. 2022 Dec 20;13(6):e0219122. doi: 10.1128/mbio.02191-22. Epub 2022 Nov 14.
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Prescription Antibiotic Use Among the US population 1999-2018: National Health and Nutrition Examination Surveys.1999 - 2018年美国人群中处方抗生素的使用情况：国家健康与营养检查调查
Open Forum Infect Dis. 2021 May 13;8(7):ofab224. doi: 10.1093/ofid/ofab224. eCollection 2021 Jul.
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BJGP Open. 2021 Aug 24;5(4). doi: 10.3399/BJGPO.2021.0020. Print 2021 Aug.
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