Riaz Zakia, Ali Murad, Abbasi Amna Didar, Khan Kamran A, Aydin Omer
Department of Aerospace Engineering, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates.
NanoThera Lab, Drug Application and Research Center (ERFARMA), Erciyes University, Kayseri 38039, Turkey.
ACS Omega. 2025 Apr 8;10(15):15052-15064. doi: 10.1021/acsomega.4c10536. eCollection 2025 Apr 22.
The growing demand for multifunctional materials in biomedical and packaging applications necessitates the development of advanced nanocomposites with superior mechanical, barrier, and antibacterial properties. This study presents cyclic olefin copolymer (COC)/titanium dioxide (TiO) nanocomposite films fabricated through the facile solution casting method, incorporating TiO at concentrations of 1, 3, and 5 wt %. Structural and morphological analyses confirmed effective TiO dispersion at lower concentrations, while agglomeration was observed at 5 wt %. The incorporation of TiO significantly enhanced barrier properties, reducing water vapor permeability from 80.67 to 29.99 g/m h and oxygen permeability from 7.66 to 2.78 mg/mL. Mechanical properties showed marked improvement, with tensile strength increasing by 113% and tensile modulus by 81.3% at 3 wt % TiO. Antibacterial tests demonstrated efficacy against and , while cytotoxicity studies confirmed the biocompatibility of the films. These findings highlight the potential of COC/TiO nanocomposites for applications, such as antibacterial coatings, wound healing patches, and high-performance packaging.
生物医学和包装应用中对多功能材料的需求不断增长，这就需要开发具有优异机械性能、阻隔性能和抗菌性能的先进纳米复合材料。本研究展示了通过简便的溶液浇铸法制备的环烯烃共聚物（COC）/二氧化钛（TiO₂）纳米复合薄膜，其中TiO₂的浓度为1%、3%和5%（质量分数）。结构和形态分析证实，在较低浓度下TiO₂能有效分散，而在5%（质量分数）时观察到团聚现象。TiO₂的加入显著提高了阻隔性能，水蒸气透过率从80.67 g/m·h降至29.99 g/m·h，氧气透过率从7.66 mg/mL降至2.78 mg/mL。机械性能有显著改善，在TiO₂含量为3%（质量分数）时，拉伸强度提高了113%，拉伸模量提高了81.3%。抗菌测试表明对[具体菌种1]和[具体菌种2]有效，而细胞毒性研究证实了薄膜的生物相容性。这些发现突出了COC/TiO₂纳米复合材料在抗菌涂层、伤口愈合贴片和高性能包装等应用中的潜力。
