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本文引用的文献

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Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial.通过音乐聆听降低重症监护病房中机械通气的老年危重症患者的谵妄发生率(DDM):一项双臂、平行组、随机临床试验。
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2
Music Interventions and Delirium in Adults: A Systematic Literature Review and Meta-Analysis.成人音乐干预与谵妄:系统文献综述与荟萃分析
Brain Sci. 2022 Apr 28;12(5):568. doi: 10.3390/brainsci12050568.
3
Positive Stimulation for Medically Sedated Patients: A Music Therapy Intervention to Treat Sedation-Related Delirium in Critical Care.对医学镇静患者的积极刺激:音乐治疗干预治疗重症监护镇静相关的谵妄。
Chest. 2022 Aug;162(2):367-374. doi: 10.1016/j.chest.2022.02.011. Epub 2022 Feb 15.
4
Association of Delirium With Long-term Cognitive Decline: A Meta-analysis.谵妄与长期认知衰退的关系:一项荟萃分析。
JAMA Neurol. 2020 Nov 1;77(11):1373-1381. doi: 10.1001/jamaneurol.2020.2273.
5
The Effect of Music on Pain in the Adult Intensive Care Unit: A Systematic Review of Randomized Controlled Trials.音乐对成人重症监护病房疼痛的影响:随机对照试验的系统评价
J Pain Symptom Manage. 2020 Jun;59(6):1304-1319.e6. doi: 10.1016/j.jpainsymman.2019.12.359. Epub 2019 Dec 24.
6
Staged Implementation of Awakening and Breathing, Coordination, Delirium Monitoring and Management, and Early Mobilization Bundle Improves Patient Outcomes and Reduces Hospital Costs.分阶段实施唤醒和呼吸、协调、谵妄监测和管理以及早期活动套餐可改善患者结局并降低医院成本。
Crit Care Med. 2019 Jul;47(7):885-893. doi: 10.1097/CCM.0000000000003765.
7
Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults.用 ABCDEF 集束化方案关爱危重症患者:15000 多例成人患者的 ICU 解放协作研究结果。
Crit Care Med. 2019 Jan;47(1):3-14. doi: 10.1097/CCM.0000000000003482.
8
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Med Care. 2018 Oct;56(10):890-897. doi: 10.1097/MLR.0000000000000975.
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Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.成人 ICU 患者疼痛、躁动/镇静、谵妄、活动减少、睡眠障碍预防与管理临床实践指南。
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Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals: Implementing PAD Guidelines Via the ABCDEF Bundle in 6,064 Patients.改善加利福尼亚州 7 家社区医院的住院患者存活率和降低其脑功能障碍发生率:通过 ABCDEF 集束干预在 6064 例患者中实施 PAD 指南。
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除了聆听音乐外,音乐疗法用于预防机械通气患者的谵妄。

Music therapy in addition to music listening for the prevention of delirium in mechanically ventilated patients.

作者信息

Crew Jeannette, Abdelmonem Ahmed, Wang Xuan, Harmon Charles, Modrykamien Ariel

机构信息

Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA.

Division of Pulmonary and Critical Care Medicine, Baylor University Medical Center, Dallas, Texas, USA.

出版信息

Proc (Bayl Univ Med Cent). 2025 Feb 28;38(3):285-290. doi: 10.1080/08998280.2025.2466931. eCollection 2025.

DOI:10.1080/08998280.2025.2466931
PMID:40291081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12026178/
Abstract

INTRODUCTION

Delirium in mechanically ventilated patients has resulted in prolonged intensive care unit (ICU) and ventilator stay and higher mortality. Research has shown that a bundle containing sedation awakening and spontaneous breathing trials, appropriate choice of sedatives, early mobilization, and family engagement was associated with a reduced rate of delirium. Music listening and music therapy have also been studied, showing promising results for anxiety and pain control, but have not been studied in terms of preventing delirium.

METHODS

As part of a quality improvement project, we implemented a protocol of music listening and music therapy for mechanically ventilated patients. The rate of delirium, ICU and ventilator lengths of stay, and mortality were compared between groups (n = 17 protocol, n = 50 control).

RESULTS

There were no statistically significant differences in demographic characteristics, severity of illness, medical comorbidities, or cumulative doses of sedating medications between the groups. The rate of delirium between groups was not statistically significantly different (11.8% vs 16%,  = 0.70). Severity of illness based on APACHE IV score was statistically associated with mortality (estimate coefficient 0.03,  = 0.015), and use of dexmedetomidine was statistically associated with prolonged ICU and ventilator lengths of stay.

CONCLUSION

The music therapy and music listening protocol did not show a reduction of the delirium rate for mechanically ventilated patients.

摘要

引言

机械通气患者的谵妄导致重症监护病房(ICU)住院时间和呼吸机使用时间延长,死亡率升高。研究表明,包含镇静唤醒与自主呼吸试验、适当选择镇静剂、早期活动及家属参与的综合措施与谵妄发生率降低相关。音乐聆听和音乐疗法也已得到研究,在焦虑和疼痛控制方面显示出有前景的结果,但在预防谵妄方面尚未进行研究。

方法

作为质量改进项目的一部分,我们为机械通气患者实施了音乐聆听和音乐疗法方案。比较了两组(n = 17例方案组,n = 50例对照组)的谵妄发生率、ICU住院时间和呼吸机使用时间以及死亡率。

结果

两组在人口统计学特征、疾病严重程度、合并症或镇静药物累积剂量方面无统计学显著差异。两组之间的谵妄发生率无统计学显著差异(11.8%对16%,P = 0.70)。基于急性生理与慢性健康状况评分系统IV(APACHE IV)评分的疾病严重程度与死亡率具有统计学相关性(估计系数0.03,P = 0.015),右美托咪定的使用与ICU住院时间和呼吸机使用时间延长具有统计学相关性。

结论

音乐疗法和音乐聆听方案并未降低机械通气患者的谵妄发生率。