Crew Jeannette, Abdelmonem Ahmed, Wang Xuan, Harmon Charles, Modrykamien Ariel
Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA.
Division of Pulmonary and Critical Care Medicine, Baylor University Medical Center, Dallas, Texas, USA.
Proc (Bayl Univ Med Cent). 2025 Feb 28;38(3):285-290. doi: 10.1080/08998280.2025.2466931. eCollection 2025.
Delirium in mechanically ventilated patients has resulted in prolonged intensive care unit (ICU) and ventilator stay and higher mortality. Research has shown that a bundle containing sedation awakening and spontaneous breathing trials, appropriate choice of sedatives, early mobilization, and family engagement was associated with a reduced rate of delirium. Music listening and music therapy have also been studied, showing promising results for anxiety and pain control, but have not been studied in terms of preventing delirium.
As part of a quality improvement project, we implemented a protocol of music listening and music therapy for mechanically ventilated patients. The rate of delirium, ICU and ventilator lengths of stay, and mortality were compared between groups (n = 17 protocol, n = 50 control).
There were no statistically significant differences in demographic characteristics, severity of illness, medical comorbidities, or cumulative doses of sedating medications between the groups. The rate of delirium between groups was not statistically significantly different (11.8% vs 16%, = 0.70). Severity of illness based on APACHE IV score was statistically associated with mortality (estimate coefficient 0.03, = 0.015), and use of dexmedetomidine was statistically associated with prolonged ICU and ventilator lengths of stay.
The music therapy and music listening protocol did not show a reduction of the delirium rate for mechanically ventilated patients.
机械通气患者的谵妄导致重症监护病房(ICU)住院时间和呼吸机使用时间延长,死亡率升高。研究表明,包含镇静唤醒与自主呼吸试验、适当选择镇静剂、早期活动及家属参与的综合措施与谵妄发生率降低相关。音乐聆听和音乐疗法也已得到研究,在焦虑和疼痛控制方面显示出有前景的结果,但在预防谵妄方面尚未进行研究。
作为质量改进项目的一部分,我们为机械通气患者实施了音乐聆听和音乐疗法方案。比较了两组(n = 17例方案组,n = 50例对照组)的谵妄发生率、ICU住院时间和呼吸机使用时间以及死亡率。
两组在人口统计学特征、疾病严重程度、合并症或镇静药物累积剂量方面无统计学显著差异。两组之间的谵妄发生率无统计学显著差异(11.8%对16%,P = 0.70)。基于急性生理与慢性健康状况评分系统IV(APACHE IV)评分的疾病严重程度与死亡率具有统计学相关性(估计系数0.03,P = 0.015),右美托咪定的使用与ICU住院时间和呼吸机使用时间延长具有统计学相关性。
音乐疗法和音乐聆听方案并未降低机械通气患者的谵妄发生率。