Midkiff Amanda K, Cook Matthew R, Vernau William, Husbands Brian D
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Metropolitan Veterinary Hospital, Highland Heights, OH, USA.
JFMS Open Rep. 2025 Apr 18;11(1):20551169251329189. doi: 10.1177/20551169251329189. eCollection 2025 Jan-Jun.
An 11-year-old male castrated domestic shorthair cat presented with increased respiratory effort, pleural effusion, lymphadenopathy, lethargy and decreased appetite with weight loss. A diagnosis of T-zone lymphoma was made from histopathology of an extirpated popliteal lymph node that had a marked paracortical expansion of small lymphocytes and prominent high endothelial venule proliferation. T-cell receptor gamma (TRG) molecular clonality PCR yielded a clonal rearrangement and immunohistochemistry demonstrated that the neoplastic lymphocytes expressed CD3 and did not express CD20. The cat was initially treated with two doses of intravenous vincristine and oral prednisolone followed by oral chlorambucil. The pleural effusion, lymphadenopathy, lymphocytosis, abdominal organomegaly and lethargy resolved, and the cat's appetite and body weight returned to normal. At the time of manuscript submission, the cat continued to do well, more than 24 months after presentation.
T-zone lymphoma is a common indolent lymphoma in dogs, but it has only been histopathologically described in one cat before this report. This is the first report to describe the clinical presentation, clinicopathologic findings and outcome for a cat with T-zone lymphoma.
一只11岁已去势的家养短毛雄性猫，出现呼吸费力、胸腔积液、淋巴结病、嗜睡、食欲减退及体重减轻。通过对切除的腘淋巴结进行组织病理学检查确诊为T区淋巴瘤，该淋巴结有明显的小淋巴细胞副皮质区扩张及显著的高内皮小静脉增殖。T细胞受体γ（TRG）分子克隆性聚合酶链反应产生克隆性重排，免疫组化显示肿瘤性淋巴细胞表达CD3而不表达CD20。这只猫最初接受了两剂静脉注射长春新碱和口服泼尼松龙治疗，随后口服苯丁酸氮芥。胸腔积液、淋巴结病、淋巴细胞增多、腹部器官肿大及嗜睡症状均得到缓解，猫的食欲和体重恢复正常。在提交本文时，这只猫在出现症状24个月多后仍状况良好。
T区淋巴瘤是犬常见的惰性淋巴瘤，但在本报告之前仅在一只猫身上有过组织病理学描述。这是第一份描述猫T区淋巴瘤临床表现、临床病理特征及转归的报告。
