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用于生物工程应用的基于立体光刻技术制造的水凝胶的开发。

Development of Hydrogels Fabricated via Stereolithography for Bioengineering Applications.

作者信息

Jeon Youngjin, Kim Minji, Song Kwang Hoon

机构信息

Department of Nano-Bioengineering, Incheon National University, 119, Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea.

Research Center of Brain-Machine Interface, Incheon National University, 119, Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea.

出版信息

Polymers (Basel). 2025 Mar 14;17(6):765. doi: 10.3390/polym17060765.

DOI:10.3390/polym17060765
PMID:40292646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11945500/
Abstract

The architectures of hydrogels fabricated with stereolithography (SLA) 3D printing systems have played various roles in bioengineering applications. Typically, the SLA systems successively illuminated light to a layer of photo-crosslinkable hydrogel precursors for the fabrication of hydrogels. These SLA systems can be classified into point-scanning types and digital micromirror device (DMD) types. The point-scanning types form layers of hydrogels by scanning the precursors with a focused light, while DMD types illuminate 2D light patterns to the precursors to form each hydrogel layer at once. Overall, SLA systems were cost-effective and allowed the fabrication of hydrogels with good shape fidelity and uniform mechanical properties. As a result, hydrogel constructs fabricated with the SLA 3D printing systems were used to regenerate tissues and develop lab-on-a-chip devices and native tissue-like models.

摘要

利用立体光刻(SLA)3D打印系统制造的水凝胶结构在生物工程应用中发挥了多种作用。通常,SLA系统依次将光照射到一层可光交联的水凝胶前体上以制造水凝胶。这些SLA系统可分为点扫描型和数字微镜器件(DMD)型。点扫描型通过用聚焦光扫描前体来形成水凝胶层,而DMD型则将二维光图案照射到前体上以一次性形成每个水凝胶层。总体而言,SLA系统具有成本效益,能够制造出形状保真度高且机械性能均匀的水凝胶。因此,用SLA 3D打印系统制造的水凝胶构建体被用于组织再生、开发芯片实验室设备和天然组织样模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/647ed149daea/polymers-17-00765-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/ffc6249ce2f7/polymers-17-00765-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/ed11d446c414/polymers-17-00765-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/5761aa3f081a/polymers-17-00765-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/c95b52e4ac55/polymers-17-00765-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/95b8203149d7/polymers-17-00765-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/a65089b27ab5/polymers-17-00765-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/5851085327d0/polymers-17-00765-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/647ed149daea/polymers-17-00765-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/ffc6249ce2f7/polymers-17-00765-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/ed11d446c414/polymers-17-00765-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/5761aa3f081a/polymers-17-00765-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/c95b52e4ac55/polymers-17-00765-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/95b8203149d7/polymers-17-00765-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/a65089b27ab5/polymers-17-00765-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/5851085327d0/polymers-17-00765-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a088/11945500/647ed149daea/polymers-17-00765-g008.jpg

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Drug Deliv Transl Res. 2025 May;15(5):1595-1608. doi: 10.1007/s13346-024-01697-5. Epub 2024 Aug 23.
2
Recent Advances in the 3D Printing of Conductive Hydrogels for Sensor Applications: A Review.用于传感器应用的导电水凝胶3D打印的最新进展:综述
Polymers (Basel). 2024 Jul 26;16(15):2131. doi: 10.3390/polym16152131.
3
In vitro degradation, swelling, and bioactivity performances of in situ forming injectable chitosan-matrixed hydrogels for bone regeneration and drug delivery.
用于骨再生和药物输送的原位形成可注射壳聚糖基质水凝胶的体外降解、溶胀和生物活性性能。
Biotechnol Bioeng. 2024 Sep;121(9):2767-2779. doi: 10.1002/bit.28755. Epub 2024 Jun 5.
4
Anisotropic hydrogel scaffold by flow-induced stereolithography 3D printing technique.流延立体光刻 3D 打印技术制备各向异性水凝胶支架。
Biomater Adv. 2024 Jul;161:213885. doi: 10.1016/j.bioadv.2024.213885. Epub 2024 May 3.
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Advances in Hydrogel-Based Drug Delivery Systems.基于水凝胶的药物递送系统的进展
Gels. 2024 Apr 13;10(4):262. doi: 10.3390/gels10040262.
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J Mech Behav Biomed Mater. 2024 Jul;155:106553. doi: 10.1016/j.jmbbm.2024.106553. Epub 2024 Apr 12.
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