布氏锥虫：培养寄生虫的感染性和免疫原性
Trypanosoma brucei: infectivity and immunogenicity of cultured parasites.
作者信息
Nyindo M, Wellde B T
出版信息
Exp Parasitol. 1985 Oct;60(2):150-4. doi: 10.1016/0014-4894(85)90017-7.
PMID:4029345
Abstract
Trypanosoma brucei brucei, derived from the salivary glands of infected tsetse flies (Glossina morsitans morsitans) and maintained in culture for over 4 years, were infective to both albino rats and tsetse flies. Virulence was markedly enhanced during the first passage in albino rats or tsetse flies. Irradiated cultured trypanosomes induced immunity to homologous challenge but not to tsetse fly or blood-induced challenge with the same stock.
摘要
源自感染采采蝇（冈比亚采采蝇）唾液腺并在培养中维持了4年以上的布氏布氏锥虫，对白化大鼠和采采蝇均具有感染性。在白化大鼠或采采蝇中的首次传代过程中，毒力显著增强。经辐照的培养锥虫可诱导对同源攻击的免疫，但对采采蝇或用同一虫株进行的血液诱导攻击则无免疫作用。
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