将急性髓系白血病分化状态绘制在骨髓图谱上。
Putting AML Differentiation States on the BoneMarrowMap.
作者信息
Berger Jonas, Penter Livius
机构信息
Department of Hematology, Oncology, and Cancer Immunology, Campus Virchow Klinikum, Berlin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin, Germany.
出版信息
Blood Cancer Discov. 2025 Jul 1;6(4):280-283. doi: 10.1158/2643-3230.BCD-25-0083.
This article presents a novel computational tool, "BoneMarrowMap," that enables the mapping of leukemic single-cell RNA sequencing datasets to hematopoietic differentiation states. By utilizing BoneMarrowMap for a large-scale single-cell RNA sequencing reanalysis, the authors discover 12 recurrent acute myeloid leukemia differentiation patterns linked to prognosis and treatment and dissect leukemic clonal architectures within individual patients. See related article by Zeng and colleagues, p. 307.
本文介绍了一种新型计算工具“骨髓图谱”，它能够将白血病单细胞RNA测序数据集映射到造血分化状态。通过利用骨髓图谱对大规模单细胞RNA测序进行重新分析，作者发现了12种与预后和治疗相关的复发性急性髓系白血病分化模式，并剖析了个体患者体内的白血病克隆结构。见曾及其同事的相关文章，第307页。
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