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Prognostic impact of clonal representation of myelodysplasia-related gene mutations in acute myeloid leukemia.

作者信息

Mecklenbrauck Rabea, Borchert Nora, Gabdoulline Razif, Poll Piroska, Funke Carolin, Brandes Maximilian, Dallmann Louisa-Kristin, Fiedler Walter, Krauter Jürgen, Trummer Arne, Hertenstein Bernd, Müller Martin, Lübbert Michael, Schwalenberg Monika, Voss Andreas, Di Donato Nataliya, Bergmann Anke, Gaidzik Verena, Döhner Konstanze, Döhner Hartmut, Ganser Arnold, Heidel Florian H, Thol Felicitas R, Heuser Michael

机构信息

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

出版信息

Leukemia. 2025 Apr 28. doi: 10.1038/s41375-025-02622-6.

DOI:10.1038/s41375-025-02622-6
PMID:40295828
Abstract
摘要

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The new diagnostic criteria for myelodysplasia-related acute myeloid leukemia is useful for predicting clinical outcome: comparison of the 4th and 5th World Health Organization classifications.骨髓增生异常综合征相关急性髓系白血病的新诊断标准有助于预测临床结局：世界卫生组织第4版和第5版分类比较
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本文引用的文献

1
Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with -mutated AML.骨髓增生异常相关及其他基因突变对接受强化治疗的FLT3突变型急性髓系白血病患者的影响。 （注：原文中“-mutated”推测可能是“FLT3-mutated”之类，这里补充完整以便更准确理解，实际翻译需根据准确原文信息）
Hemasphere. 2025 Jan 15;9(1):e70060. doi: 10.1002/hem3.70060. eCollection 2025 Jan.
2
Mutations highly specific for secondary AML are associated with poor outcomes in ELN favorable risk NPM1-mutated AML.与 ELN 有利风险 NPM1 突变型 AML 中次级 AML 高度特异性的突变与不良预后相关。
Blood Adv. 2024 Mar 12;8(5):1075-1083. doi: 10.1182/bloodadvances.2023011173.
3
Secondary-type mutations do not impact outcome in NPM1-mutated acute myeloid leukemia - implications for the European LeukemiaNet risk classification.
继发性类型突变不影响NPM1突变型急性髓系白血病的预后——对欧洲白血病网风险分类的意义
Leukemia. 2023 Nov;37(11):2282-2285. doi: 10.1038/s41375-023-02016-6. Epub 2023 Sep 7.
4
Applicability of 2022 classifications of acute myeloid leukemia in the real-world setting.2022 年急性髓系白血病分类在真实世界中的适用性。
Blood Adv. 2023 Sep 12;7(17):5122-5131. doi: 10.1182/bloodadvances.2023010173.
5
Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group.比较 PETHEMA 组真实队列中 2022 年和 2017 年欧洲白血病网络风险分类。
Blood Cancer J. 2023 May 12;13(1):77. doi: 10.1038/s41408-023-00835-5.
6
AML classification in the year 2023: How to avoid a Babylonian confusion of languages.2023 年的 AML 分类：如何避免语言的巴别塔式混乱。
Leukemia. 2023 Jul;37(7):1413-1420. doi: 10.1038/s41375-023-01909-w. Epub 2023 Apr 29.
7
Validation and refinement of the 2022 European LeukemiaNet genetic risk stratification of acute myeloid leukemia.验证和改进 2022 年欧洲白血病网络急性髓系白血病的遗传风险分层。
Leukemia. 2023 Jun;37(6):1234-1244. doi: 10.1038/s41375-023-01884-2. Epub 2023 Apr 11.
8
Poor prognostic implications of myelodysplasia-related mutations in both older and younger patients with de novo AML.新诊断为 AML 的老年和年轻患者中存在骨髓增生异常相关突变提示预后不良。
Blood Cancer J. 2023 Jan 4;13(1):4. doi: 10.1038/s41408-022-00774-7.
9
Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia.比较和验证 2022 年欧洲白血病网络指南在急性髓细胞白血病中的应用。
Blood Adv. 2023 May 9;7(9):1899-1909. doi: 10.1182/bloodadvances.2022009010.
10
Unified classification and risk-stratification in Acute Myeloid Leukemia.急性髓系白血病的统一分类和危险分层。
Nat Commun. 2022 Aug 8;13(1):4622. doi: 10.1038/s41467-022-32103-8.