Chen Junyu, Fu Dihan, Ma Tianqi, Chen Minghong, Wang Xuerui, Yi Jun
Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, Hunan, China.
BMC Womens Health. 2025 Apr 28;25(1):207. doi: 10.1186/s12905-025-03749-5.
Metabolic disorders have a significant impact on the health of women of childbearing age (WCBA) but remain underemphasized. This study aims to assess the global, regional, and national burden of metabolic disorders in WCBA from 1990 to 2021.
Prevalence, mortality, and disability-adjusted life years (DALYs) related to metabolic disorders in WCBA from 1990 to 2021 were obtained from the Global Burden of Disease (GBD) 2021. Annual percentage changes were calculated, and stratified analyses were conducted based on age, region, nation, and socio-demographic index levels to assess the distribution of metabolic disorders in WCBA.
Globally, the overall burden of metabolic disorders among WCBA has increased. In 2021, obesity (330.21 [148.37-518.36]) had the highest age-standardized DALYs rate, followed by hypertension (200.75 [154.67-245.47]), type 2 diabetes mellitus (175.11 [134.18-223.42]), hyperlipidemia (139.02 [101.32-173.61]), and non-alcoholic fatty liver disease (10.1 [7.17-13.92]). The most significant changes of the overall metabolic disorders burden in WCBA were observed in younger age groups. The burden of metabolic disorders was higher in less-developed regions.
Given the marked increase in the burden of metabolic disorders among younger WCBA, it is recommended that healthcare management be reinforced for this demographic. Furthermore, based on the varying burdens observed across regions, targeted metabolic interventions for WCBA should be tailored to local conditions.
代谢紊乱对育龄妇女的健康有重大影响，但仍未得到足够重视。本研究旨在评估1990年至2021年全球、区域和国家育龄妇女代谢紊乱的负担。
从《2021年全球疾病负担》（GBD 2021）中获取1990年至2021年育龄妇女与代谢紊乱相关的患病率、死亡率和伤残调整生命年（DALYs）。计算年度百分比变化，并根据年龄、地区、国家和社会人口指数水平进行分层分析，以评估育龄妇女代谢紊乱的分布情况。
在全球范围内，育龄妇女代谢紊乱的总体负担有所增加。2021年，肥胖（330.21 [148.37 - 518.36]）的年龄标准化DALYs率最高，其次是高血压（200.75 [154.67 - 245.47]）、2型糖尿病（175.11 [134.18 - 223.42]）、高脂血症（139.02 [101.32 - 173.61]）和非酒精性脂肪性肝病（10.1 [7.17 - 13.92]）。育龄妇女总体代谢紊乱负担的最显著变化出现在较年轻年龄组。代谢紊乱负担在欠发达地区更高。
鉴于年轻育龄妇女代谢紊乱负担显著增加，建议加强对这一人群的医疗管理。此外，根据各地区观察到的不同负担情况，应针对当地情况为育龄妇女量身定制有针对性的代谢干预措施。
