Behme Stephanie, Girgis Christopher, Schmidt Brian M
Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Health, Ann Arbor, Michigan, USA.
Int J Low Extrem Wounds. 2025 Apr 29:15347346251337862. doi: 10.1177/15347346251337862.
Development of the triad of peripheral arterial disease, peripheral neuropathy, and end stage renal disease puts people with diabetes at an increased risk of diabetic foot ulcerations and subsequent infections that often precede lower extremity amputations. In patients on hemodialysis, there is a ten-fold increased risk of amputation and an estimated 40%-82% one-year mortality rate if the amputation is a major amputation. This study aimed to examine if patients presenting to a podiatric clinic with stage 3a or 3b chronic kidney disease and a diabetic foot ulcer had decreased rates of amputations as compared to patients who presented after initiating dialysis. Our results demonstrated all major amputations occurred in patients who did not establish with podiatry prior to initiating HD. Additionally, our study revealed a potential access to care disparity for African American patients with chronic kidney disease, as African American patients were established with podiatry prior to initiating dialysis less often in comparison to Caucasian individuals. Our study lays the groundwork for future work investigating the impact of podiatric surveillance on patients with diabetes and end stage renal disease.
外周动脉疾病、外周神经病变和终末期肾病三联征的出现,使糖尿病患者发生糖尿病足溃疡及后续感染的风险增加,而这些情况往往先于下肢截肢。在接受血液透析的患者中,如果进行的是大截肢手术,截肢风险会增加10倍,估计一年死亡率为40%-82%。本研究旨在检验,与开始透析后前来就诊的患者相比,因患有3a期或3b期慢性肾病和糖尿病足溃疡而到足病诊所就诊的患者截肢率是否降低。我们的结果表明,所有大截肢手术均发生在开始血液透析前未接受足病治疗的患者中。此外,我们的研究揭示了非裔美国慢性肾病患者在获得医疗服务方面可能存在的差异,因为与白种人相比,非裔美国患者在开始透析前接受足病治疗的情况较少。我们的研究为未来调查足病监测对糖尿病和终末期肾病患者的影响奠定了基础。