Kouthoofd Gioia S, Peters Ester M, Jaquet Jean-Bart
Department of Plastic Surgery, Amphia Hospital, Breda, NLD.
Department of Plastic and Reconstructive Surgery, Maasstad Hospital, Rotterdam, NLD.
Cureus. 2025 Mar 27;17(3):e81294. doi: 10.7759/cureus.81294. eCollection 2025 Mar.
Background Scars are known to negatively impact patients' quality of life or even disable them. A broad spectrum of different scar treatments is used in clinical practice. Platelet-rich plasma (PRP) and microneedling are promising treatments that enhance tissue regeneration. The aim of this study was to evaluate the safety, clinical effects, and patients' experience of a combination treatment consisting of a series of PRP plus microneedling. Methods One hundred seven patients with scars, with various etiology and scar age, were included in our study. PRP had been prepared using the ACP double syringe system and was injected with high pressure into the dermis of the affected tissue, using the U225 meso injector as an injection and microneedling device. This treatment was applied three times at four-week intervals. On the days of treatment and at the 4-week follow-up, patient records were collected and clinical investigations and interviews were performed to assess clinical effects, adverse effects, and patient's experience. Results The results of this retrospective study indicate that 23 patients (21.5%) reported softer and more elastic scar tissue, 8 patients (7.5%) experienced improved mobility and functionality, 6 patients (5.6%) showed an overall healthier skin appearance, and 8 (7.5%) patients observed an improvement in color. Adverse effects reported were mild and only temporary. Twenty-three (21.5%) patients felt stressed before the treatment, and 12 patients (11.2%) reported tenderness during the first treatment of which two rated it as mildly painful. After the first treatment, two patients (1.9%) reported transient itchiness. Serious adverse effects did not occur. Conclusions PRP plus microneedling can enhance the pliability, mobility, and color of different scar types and scar ages. Overall, the treatment was easily feasible, well-tolerated and safe. Therefore, it can be considered a promising new treatment modality for scar management.
背景 众所周知，瘢痕会对患者的生活质量产生负面影响，甚至导致患者残疾。临床实践中使用了多种不同的瘢痕治疗方法。富血小板血浆（PRP）和微针疗法是有前景的促进组织再生的治疗方法。本研究的目的是评估一系列PRP联合微针疗法的联合治疗的安全性、临床效果和患者体验。
方法 本研究纳入了107例病因和瘢痕形成时间各异的瘢痕患者。使用ACP双注射器系统制备PRP，并使用U225中胚层注射器作为注射和微针设备，将其高压注入受影响组织的真皮层。该治疗每四周进行一次，共进行三次。在治疗当天和4周随访时，收集患者记录，并进行临床检查和访谈，以评估临床效果、不良反应和患者体验。
结果 这项回顾性研究的结果表明，23例患者（21.5%）报告瘢痕组织更柔软、更有弹性，8例患者（7.5%）的活动度和功能得到改善，6例患者（5.6%）的整体皮肤外观更健康，8例患者（7.5%）的颜色有所改善。报告的不良反应较轻，且只是暂时的。23例患者（21.5%）在治疗前感到紧张，12例患者（11.2%）在首次治疗时报告有压痛，其中2例将其评为轻度疼痛。首次治疗后，2例患者（1.9%）报告有短暂瘙痒。未发生严重不良反应。
结论 PRP联合微针疗法可改善不同类型和形成时间的瘢痕的柔韧性、活动度和颜色。总体而言，该治疗易于实施，耐受性良好且安全。因此，它可被视为一种有前景的瘢痕管理新治疗方式。
