Hunt James Russell, Knazovicky David, Goff Megan, Harris John, Knowles Toby G, Enomoto Masataka, Mendl Michael, Whay Becky, Lascelles B Duncan X, Murrell Joanna C
Bristol Veterinary School, University of Bristol, Bristol, United Kingdom.
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.
Front Pain Res (Lausanne). 2025 Apr 14;6:1518725. doi: 10.3389/fpain.2025.1518725. eCollection 2025.
To investigate changes in somatosensory sensitivity in dogs with spontaneous osteoarthritis (OA) and pain of the stifle or hip, compared to a group of healthy control dogs.
A non-randomised, non-blinded, prospective research study.
30 control, 51 OA-pain, and 31 OA-pain dogs receiving NSAIDs.
A range of noxious and non-noxious quantitative sensory testing (QST) modalities were applied. Dogs were tested twice, one month apart. Two sites were tested at each visit: a distal site located on the cranial aspect of the mid metatarsus and a primary site, lateral to the patella (in dogs with stifle OA) or craniodorsally to the greater trochanter (in dogs with coxofemoral OA). Control dogs were tested at appropriate primary sites to produce the same proportion of animals being tested at stifle or hip as those in the OA group. The order in which non-nociceptive and nociceptive tests were performed was randomized for each test site for each animal, although nociceptive tests were always performed after non-nociceptive tests. Feasibility for performing the tests was assessed for the final 45 dogs recruited to the study. The hierarchical structure of the QST testing data was accounted for within the statistical analysis by employing general linear modelling within a multilevel modelling framework using the MLwiN statistics package.
Osteoarthritis category was not a major determinant of QST outcome measures for the majority of modalities evaluated. In the few modalities in which OA category was determined to be a significant predictor variable, the results were not consistent with previously reported data. The novel, non-nociceptive tests employed overall suggested non-noxious hypoesthesia in association with OA pain. The feasibility of performing QST assessments was relatively low compared to previous studies.
and clinical relevance: In a clinical environment, the variability in feasibility of performing QST between dogs may be sufficient to confound changes in QST outcome measures associated with spontaneous OA.
与一组健康对照犬相比，研究患有自发性骨关节炎（OA）且伴有 stifle 关节或髋关节疼痛的犬的躯体感觉敏感性变化。
一项非随机、非盲法的前瞻性研究。
30 只对照犬、51 只 OA 疼痛犬以及 31 只接受非甾体抗炎药治疗的 OA 疼痛犬。
应用了一系列有害和无害的定量感觉测试（QST）方法。犬只接受两次测试，间隔一个月。每次测试两个部位：一个位于跖骨中部颅侧的远端部位，以及一个主要部位，在 stifle 关节 OA 的犬中位于髌骨外侧，在股髋 OA 的犬中位于大转子颅背侧。对照犬在适当的主要部位进行测试，以使在 stifle 关节或髋关节接受测试的动物比例与 OA 组相同。对于每只动物的每个测试部位，非伤害性和伤害性测试的执行顺序是随机的，不过伤害性测试总是在非伤害性测试之后进行。对纳入研究的最后 45 只犬评估了进行测试的可行性。通过使用 MLwiN 统计软件包在多水平建模框架内采用一般线性模型，在统计分析中考虑了 QST 测试数据的层次结构。
对于大多数评估的方法，骨关节炎类别并非 QST 结果测量的主要决定因素。在少数几种确定 OA 类别为显著预测变量的方法中，结果与先前报道的数据不一致。所采用的新型非伤害性测试总体上表明与 OA 疼痛相关的无害性感觉减退。与先前的研究相比，进行 QST 评估的可行性相对较低。
在临床环境中，犬之间进行 QST 的可行性差异可能足以混淆与自发性 OA 相关的 QST 结果测量的变化。
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