Williams Morika D, Kirkpatrick Amy E, Griffith Emily, Benito Javier, Hash Jon, Lascelles B D X
Comparative Pain Research Laboratory (CPRL), Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
Center for Comparative Medicine and Translational Research, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA; Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA.
Vet J. 2014 Jan;199(1):63-7. doi: 10.1016/j.tvjl.2013.11.003. Epub 2013 Nov 11.
The objectives of this study were to determine whether thermal quantitative sensory testing (QST) can be performed in client-owned dogs, is repeatable and whether QST differs between normal dogs and dogs with hind limb osteoarthritis (OA). This clinical, prospective, observational study used clinically normal dogs (n=23) and dogs with OA-associated hind limb pain (n=9). Thermal QST was performed in standing dogs using a high-powered light source delivered by a previously validated system. Dogs were tested on two occasions, 2 weeks apart. Five tests were performed on each hind limb at each time point. Repeated measures analysis of variance was used to evaluate the effects of leg, time point and OA/normal status on thermal threshold latencies (TTL). Additionally, paired t tests were used to compare the TTL of left and right limbs within groups and between time points. Thermal thresholds were successfully measured in 32 client-owned dogs without prior training. TTL were significantly different between normal and OA dogs (P=0.012). There was no difference between limbs (P=0.744) or time periods (P=0.572), when analyzed by repeated measures analysis of variance, and no interactions between group and limb, visit and limb, or visit and group. In conclusion, thermal thresholds can be measured in client owned dogs with no prior training and are repeatable from week to week. Further data are required to determine if OA results in thermal hypoalgesia as measured at the distal hind limb and whether this is an indication of central sensitization.
本研究的目的是确定热定量感觉测试（QST）是否可以在客户拥有的犬只中进行、是否具有可重复性，以及正常犬只和患有后肢骨关节炎（OA）的犬只之间的QST是否存在差异。这项临床前瞻性观察研究使用了临床正常的犬只（n = 23）和患有与OA相关后肢疼痛的犬只（n = 9）。使用先前经过验证的系统提供的高功率光源，对站立的犬只进行热QST测试。犬只在两个时间点进行测试，间隔2周。每个时间点对每个后肢进行5次测试。采用重复测量方差分析来评估腿部、时间点以及OA/正常状态对热阈值潜伏期（TTL）的影响。此外，使用配对t检验来比较组内和不同时间点左右肢的TTL。在未经事先训练的32只客户拥有的犬只中成功测量了热阈值。正常犬只和患OA犬只之间的TTL存在显著差异（P = 0.012）。通过重复测量方差分析，肢体之间（P = 0.744）或时间段之间（P = 0.572）没有差异，并且组与肢体、就诊与肢体或就诊与组之间没有相互作用。总之，无需事先训练即可在客户拥有的犬只中测量热阈值，并且每周可重复测量。需要进一步的数据来确定OA是否会导致后肢远端测量的热痛觉减退，以及这是否是中枢敏化的一个指标。
