Harris L K, Whay H R, Murrell J C
School of Veterinary Sciences, University of Bristol, Langford, North Somerset BS40 5DU, UK.
School of Veterinary Sciences, University of Bristol, Langford, North Somerset BS40 5DU, UK.
Vet J. 2018 Apr;234:85-90. doi: 10.1016/j.tvjl.2017.12.012. Epub 2017 Dec 15.
This study investigated the effects of osteoarthritis (OA) on somatosensory processing in dogs using mechanical threshold testing. A pressure algometer was used to measure mechanical thresholds in 27 dogs with presumed hind limb osteoarthritis and 28 healthy dogs. Mechanical thresholds were measured at the stifles, radii and sternum, and were correlated with scores from an owner questionnaire and a clinical checklist, a scoring system that quantified clinical signs of osteoarthritis. The effects of age and bodyweight on mechanical thresholds were also investigated. Multiple regression models indicated that, when bodyweight was taken into account, dogs with presumed osteoarthritis had lower mechanical thresholds at the stifles than control dogs, but not at other sites. Non-parametric correlations showed that clinical checklist scores and questionnaire scores were negatively correlated with mechanical thresholds at the stifles. The results suggest that mechanical threshold testing using a pressure algometer can detect primary, and possibly secondary, hyperalgesia in dogs with presumed osteoarthritis. This suggests that the mechanical threshold testing protocol used in this study might facilitate assessment of somatosensory changes associated with disease progression or response to treatment.
本研究使用机械阈值测试，调查了骨关节炎（OA）对犬体感处理的影响。使用压力痛觉计测量了27只推测患有后肢骨关节炎的犬和28只健康犬的机械阈值。在膝关节、桡骨和胸骨处测量机械阈值，并将其与主人问卷和临床检查表的评分相关联，该评分系统对骨关节炎的临床体征进行量化。还研究了年龄和体重对机械阈值的影响。多元回归模型表明，在考虑体重因素时，推测患有骨关节炎的犬在膝关节处的机械阈值低于对照犬，但在其他部位则不然。非参数相关性分析显示，临床检查表评分和问卷评分与膝关节处的机械阈值呈负相关。结果表明，使用压力痛觉计进行机械阈值测试可以检测出推测患有骨关节炎的犬的原发性，甚至可能是继发性痛觉过敏。这表明本研究中使用的机械阈值测试方案可能有助于评估与疾病进展或治疗反应相关的体感变化。
