Wenqiu Chen, Jingxian Duan, Sujiao Sun
Department of Dermatology, Yantian District People's Hospital, Shenzhen, China.
Department of Medical Cosmetology, Dali University, Dali, China.
Arch Dermatol Res. 2025 Apr 29;317(1):742. doi: 10.1007/s00403-025-04201-2.
Acne frequently coexists with atrophic scars, yet clinical management typically follows a stepwise approach, with limited evidence on the efficacy of simultaneous treatment strategies for both conditions. To address this gap, we conducted a prospective split-face controlled trial involving 30 patients with symmetrical bilateral facial acne lesions and atrophic scars. The right side of the face was assigned to the stepwise treatment group, receiving 30% supramolecular salicylic acid for acne every two weeks for a total of five sessions. Following the resolution of inflammatory lesions, microneedling and subcision were performed for atrophic scars once a month for three sessions. The left side was designated as the simultaneous treatment group, receiving combined therapy (supramolecular salicylic acid, microneedling, and subcision) for both acne and atrophic scars once a month for three sessions.Efficacy and safety were assessed during follow-up. Results demonstrated that the simultaneous treatment regimen was significantly more effective in reducing acne lesions compared to the stepwise approach (P < 0.05), while both regimens showed comparable efficacy in improving atrophic scars (P > 0.05). No significant adverse reactions were observed in either group. Notably, the simultaneous treatment regimen significantly reduced the overall treatment duration and achieved higher patient satisfaction compared to the stepwise approach.In conclusion, the simultaneous treatment of acne and atrophic scars is not only clinically effective and safe but also offers the advantages of shorter treatment duration and enhanced patient satisfaction, making it a promising therapeutic strategy.
痤疮常与萎缩性瘢痕同时存在，但临床治疗通常采用逐步治疗方法，对于这两种情况同时治疗策略的疗效证据有限。为填补这一空白，我们进行了一项前瞻性半脸对照试验，纳入了30例双侧面部痤疮皮损和萎缩性瘢痕对称的患者。面部右侧被分配到逐步治疗组，每两周接受一次30%超分子水杨酸治疗痤疮，共进行5次治疗。炎症性皮损消退后，每月对萎缩性瘢痕进行一次微针和皮下分离治疗，共进行3次治疗。左侧被指定为同时治疗组，每月对痤疮和萎缩性瘢痕进行联合治疗（超分子水杨酸、微针和皮下分离），共进行3次治疗。随访期间评估疗效和安全性。结果表明，与逐步治疗方法相比，同时治疗方案在减少痤疮皮损方面显著更有效（P < 0.05），而两种方案在改善萎缩性瘢痕方面疗效相当（P > 0.05）。两组均未观察到明显的不良反应。值得注意的是，与逐步治疗方法相比，同时治疗方案显著缩短了总体治疗时间并获得了更高的患者满意度。总之，痤疮和萎缩性瘢痕的同时治疗不仅在临床上有效且安全，而且具有治疗时间短和患者满意度提高的优点，使其成为一种有前景的治疗策略。
