Liu Xueying, Huang Linjing, Zhu Youzhi, Wu Peiwen
Department of Endocrinology, the First Affiliated Hospital, Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, Fujian, China.
Department of Endocrinology, Fuqing City Hospital, Fujian Medical University, Fuzhou, 350300, Fujian, China.
Biometals. 2025 Apr 29. doi: 10.1007/s10534-025-00682-w.
This study aims to compare variations in 18 trace elements (Al, Na, K, Mg, Ca, Ti, Ba, Sn, Cr, Mn, Fe, Cu, Zn, Se, Mo, Cd, Sr, and Tl) between benign and malignant thyroid tissues. Post-operative thyroid tissue samples were collected from 106 patients (34 benign, 72 malignant), and elemental concentrations were quantified using inductively coupled plasma mass spectrometry. Spearman's correlation analysis revealed positive correlations among these trace elements. Notably, the malignant group exhibited significantly higher concentrations in eight elements (Mg, Al, Fe, Cr, Ti, Sr, Sn, and Ba) compared to the benign group, while levels of six elements (Na, Mn, Cu, Zn, Cd, and Mo) were significantly lower. Orthogonal partial least squares discriminant analysis distinguished three elements (Al, Ti, Sn) for the malignant group and six elements (Na, Mn, Cu, Zn, Cd, and Mo) for the benign group. Multivariate logistic regression further revealed associations between thyroid cancer and levels of Al, Cr, Ti, Sr, Sn, Ba, Mn, Cu, Zn, and Cd. Considering with each elemental biological funcions, these findings suggest that Cu, Mn, and particularly Zn may act as essential antitumor elements with synergistic effects, whereas elevated Ba, Cr, and Al levels are closely related to thyroid malignancies. However deficiencies and excesses of elements may be the consequences of malignant tissues. In conclusion, benign and malignant thyroid tumors exhibit different trace-element profiles.
本研究旨在比较良性和恶性甲状腺组织中18种微量元素（铝、钠、钾、镁、钙、钛、钡、锡、铬、锰、铁、铜、锌、硒、钼、镉、锶和铊）的差异。从106例患者（34例良性，72例恶性）收集术后甲状腺组织样本，并使用电感耦合等离子体质谱法定量元素浓度。Spearman相关性分析显示这些微量元素之间存在正相关。值得注意的是，与良性组相比，恶性组中八种元素（镁、铝、铁、铬、钛、锶、锡和钡）的浓度显著更高，而六种元素（钠、锰、铜、锌、镉和钼）的水平显著更低。正交偏最小二乘法判别分析区分出恶性组的三种元素（铝、钛、锡）和良性组的六种元素（钠、锰、铜、锌、镉和钼）。多变量逻辑回归进一步揭示了甲状腺癌与铝、铬、钛、锶、锡、钡、锰、铜、锌和镉水平之间的关联。考虑到每种元素的生物学功能，这些发现表明铜、锰，特别是锌可能作为具有协同作用的必需抗肿瘤元素，而钡、铬和铝水平升高与甲状腺恶性肿瘤密切相关。然而，元素的缺乏和过量可能是恶性组织的后果。总之，良性和恶性甲状腺肿瘤表现出不同的微量元素谱。
