Department of Dietetics and Bromatology, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Nutrients. 2023 Jun 2;15(11):2619. doi: 10.3390/nu15112619.
The aim of this study was to evaluate alterations in blood parameters after a low-carbohydrate high-fat (LCHF) diet in women with lipedema in comparison to overweight or obese women. A total of 115 women were classified into two groups: the lipedema group and the overweight/obesity group. Both study groups followed the caloric-restricted LCHF diet for 7 months. A total of 48 women completed the study. A reduction in body weight was observed in both study groups. A significant decrease in triglycerides and an increase in HDL-C concentrations were observed in both study groups. Despite the increase in the concentration of LDL-C observed in the lipedema group, changes in LDL-C differed between individual patients. Improvements in liver parameters, glucose tolerance, and a decrease in fasting insulin levels were observed, although they were less pronounced in the lipedema group than in the overweight/obesity group. Kidney and thyroid functions were similar before and after the LCHF diet in both groups. The LCHF diet may be a valuable nutritional strategy for lipedema and overweight/obese women, with a beneficial effect on weight, glucose profile, liver function, the concentration of triglycerides, and HDL-C and with no effect on kidney and thyroid function.
本研究旨在评估低碳水化合物高脂肪（LCHF）饮食对脂肪水肿女性与超重或肥胖女性的血液参数变化。共有 115 名女性被分为两组：脂肪水肿组和超重/肥胖组。两组研究对象均遵循热量限制的 LCHF 饮食 7 个月。共有 48 名女性完成了研究。两组研究对象的体重均有所减轻。两组研究对象的甘油三酯水平显著降低，HDL-C 浓度升高。尽管脂肪水肿组的 LDL-C 浓度有所增加，但 LDL-C 的变化在个体患者之间存在差异。尽管脂肪水肿组的改善程度不如超重/肥胖组明显，但肝脏参数、葡萄糖耐量和空腹胰岛素水平均有所改善。两组患者的肾脏和甲状腺功能在接受 LCHF 饮食前后相似。LCHF 饮食可能是治疗脂肪水肿和超重/肥胖女性的一种有价值的营养策略，对体重、血糖谱、肝功能、甘油三酯和 HDL-C 浓度有有益影响，对肾脏和甲状腺功能无影响。
