Luquiens Amandine, Panjo Henri, Dereux Alexandra, Louville Patrice, Donnadieu Hélène, Bronnec Marie, Benyamina Amine, Perney Pascal, Carré Arnaud, Pelletier-Fleury Nathalie
University of Montpellier. Department of Addiction, Universitary Hospital of Nîmes, Nîmes, France.
CESP, University Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.
PLoS One. 2025 Apr 29;20(4):e0321365. doi: 10.1371/journal.pone.0321365. eCollection 2025.
Short versions of health-related quality of life measures are essential for the development of preference-based measures used to obtain the quality-adjustment weights needed to calculate quality-adjusted life years (QALYs) in health economic evaluations. Using data from the randomized TRAIN study, which compared the efficacy of two cognitive training programs in patients with alcohol use disorder (AUD) recently detoxified at five centers in France from 2019 to 2023 (n=227), we report the development and psychometrics of the AQoLS-Brief, a short version of the initial 34-item Alcohol Quality of Life Scale (AQoLS).
Baseline data on, age, sex, AUD severity, drinking characteristics and consequences of alcohol including the AQoLS were collected. One item per dimension of the AQoLS was chosen following predefined rules. Construct validity of the AQoLS-brief was documented: internal consistency was assessed using Cronbach's alpha and external validity was assessed with external drinking and non-drinking variables via univariate analyses, a confirmatory factorial analysis (CFA) and a multivariate linear regression.
The 7-item AQoLS-Brief demonstrated good internal consistency (Cronbach alpha= 0.80) and very high correlation with the long version AQoLS (rho=0.95). The CFA confirmed the unidimensionality of the AQoLS-Brief. Severity of AUD, as measured by the number of DSM-5 alcohol criteria and the number of heavy drinking days, and the dimension Sadness of the Affective Neuroscience Personality Scales were the heaviest contributors to the AQoLS-Brief score.
The AQoLS-Brief is a short version of the AQoLS with good psychometrics, enhancing its use in clinical practice and research, and representing a significant step toward establishing a relevant and specific preference-based measures for calculating QALYs in AUD populations.
与健康相关的生活质量测量的简短版本对于基于偏好的测量方法的开发至关重要，这些测量方法用于获取在健康经济评估中计算质量调整生命年（QALY）所需的质量调整权重。利用随机TRAIN研究的数据，该研究比较了2019年至2023年在法国五个中心近期戒酒的酒精使用障碍（AUD）患者中两种认知训练项目的疗效（n = 227），我们报告了AQoLS-Brief的开发和心理测量学特征，它是最初34项酒精生活质量量表（AQoLS）的简短版本。
收集了关于年龄、性别、AUD严重程度、饮酒特征和酒精后果（包括AQoLS）的基线数据。按照预定义规则从AQoLS的每个维度中选择一个项目。记录了AQoLS-brief的结构效度：使用Cronbach's alpha评估内部一致性，并通过单变量分析、验证性因子分析（CFA）和多元线性回归，用外部饮酒和非饮酒变量评估外部效度。
7项AQoLS-Brief表现出良好的内部一致性（Cronbach alpha = 0.80），并且与长版本AQoLS的相关性非常高（rho = 0.95）。CFA证实了AQoLS-Brief的单维度性。以DSM-5酒精标准数量和重度饮酒天数衡量的AUD严重程度，以及情感神经科学人格量表的悲伤维度是AQoLS-Brief得分的最大贡献因素。
AQoLS-Brief是AQoLS的简短版本，具有良好的心理测量学特征，增强了其在临床实践和研究中的应用，代表了朝着为AUD人群建立相关且特定的基于偏好的QALY计算测量方法迈出的重要一步。
