甘油三酯葡萄糖-腰围身高比与无症状颅内动脉狭窄的关联。

Association of the triglyceride glucose-waist height ratio with asymptomatic intracranial arterial stenosis.

作者信息

Yang Yumeng, Guo Liying, Song Shiqing, Kong Xianglong, Zhao Yuanyuan, Ma Xiaotong, Wang Xiang, Wang Hailing, Sun Qinjian

机构信息

Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.

Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

出版信息

Lipids Health Dis. 2025 Apr 29;24(1):161. doi: 10.1186/s12944-025-02562-1.

DOI:10.1186/s12944-025-02562-1

PMID:40301904

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12039148/

Abstract

BACKGROUND AND OBJECTIVE

This study evaluated the associations of the triglyceride-glucose (TyG) index or its attendant parameters, known as reliable measures of insulin resistance, with asymptomatic intracranial arterial stenosis (aICAS), along with their value for distinguishing individuals with a notable aICAS burden.

METHODS

This study enrolled 2000 participants (aged ≥ 40 years) based on the Rose asymptomatic IntraCranial Artery Stenosis study. Transcranial Doppler ultrasound combined with magnetic resonance angiography was utilized to confirm aICAS. Logistic regression was applied to assess the associations between TyG or TyG-related indices (TyG-body mass index, TyG-waist circumference [TyG-WC], TyG-waist-to-hip ratio [TyG-WHR], or TyG-waist-to-height ratio [TyG-WHtR]) and aICAS. The diagnostic potential of them was investigated using receiver operating characteristic (ROC) analysis.

RESULTS

Among the 2000 participants, 146 (7.3%) had a diagnosis of aICAS. TyG-WC, TyG-WHR, or TyG-WHtR were independently related to the prevalence of aICAS (TyG-WC: OR 1.26, 95%CI 1.03-1.54; TyG-WHR: OR 1.29, 95%CI 1.07-1.55; TyG-WHtR: OR 1.25, 95%CI 1.04-1.51). ROC analysis disclosed that TyG-WHtR had significant superior performance in identifying aICAS compared with other parameters (all P < 0.05). Subgroup analysis revealed that higher TyG-WHtR values showed a positive association with a heightened prevalence of aICAS observed in elderly participants aged ≥ 65 years (OR 1.69, 95%CI 1.20-2.38), and hypertensive patients (OR 1.30, 95%CI 1.06-1.59).

CONCLUSION

The association of TyG-WHtR with aICAS showed that TyG-WHtR might be a more effective indicator for identifying populations with early-stage aICAS.

摘要

背景与目的

本研究评估了甘油三酯-葡萄糖（TyG）指数或其相关参数（作为胰岛素抵抗的可靠指标）与无症状颅内动脉狭窄（aICAS）的关联，以及它们在区分具有显著aICAS负担个体方面的价值。

方法

本研究基于罗斯无症状颅内动脉狭窄研究招募了2000名参与者（年龄≥40岁）。采用经颅多普勒超声联合磁共振血管造影来确认aICAS。应用逻辑回归评估TyG或TyG相关指数（TyG-体重指数、TyG-腰围[TyG-WC]、TyG-腰臀比[TyG-WHR]或TyG-腰高比[TyG-WHtR]）与aICAS之间的关联。使用受试者工作特征（ROC）分析研究它们的诊断潜力。

结果

在2000名参与者中，146名（7.3%）被诊断为aICAS。TyG-WC、TyG-WHR或TyG-WHtR与aICAS的患病率独立相关（TyG-WC：比值比1.26，95%置信区间1.03 - 1.54；TyG-WHR：比值比1.29，95%置信区间1.07 - 1.55；TyG-WHtR：比值比1.25，95%置信区间1.04 - 1.51）。ROC分析显示，与其他参数相比，TyG-WHtR在识别aICAS方面具有显著更优的性能（所有P < 0.05）。亚组分析显示，较高的TyG-WHtR值与≥65岁老年参与者（比值比1.69，95%置信区间1.20 - 2.38）和高血压患者（比值比1.30，95%置信区间1.06 - 1.59）中观察到的aICAS患病率升高呈正相关。