Liu Ming, Yang Ping, Gou Yunpeng
Department of Pediatric Surgery, Suining Central Hospital, Suining, Sichuan, China.
Front Endocrinol (Lausanne). 2025 Jan 7;15:1516982. doi: 10.3389/fendo.2024.1516982. eCollection 2024.
The triglyceride-glucose (TyG) index and related indices, including the triglyceride-glucose body mass index (TyG-BMI), triglyceride-glucose waist circumference (TyG-WC), and triglyceride-glucose waist-to-height ratio (TyG-WHtR), are increasingly recognized as valuable markers of insulin resistance (IR). This study aimed to assess the associations between these TyG-related indices and kidney stones.
This cross-sectional study analyzed data from 10,824 participants obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2020. Weighted logistic regression models were employed to evaluate the associations between TyG-related indices and kidney stones, with adjustments for potential confounding factors. Subgroup analyses and smooth curve fittings were performed to further examine these associations, while receiver operating characteristic (ROC) curves were used to compare the predictive performance of each index.
All TyG-related indices demonstrated significant positive associations with kidney stones when analyzed as continuous variables. The odds ratios (OR) with 95% confidence intervals (CI) were 1.0040 (1.0028, 1.0052) for TyG-BMI, 1.0015 (1.0011, 1.0020) for TyG-WC, and 1.3305 (1.2277, 1.4419) for TyG-WHtR. Similar trends were observed in subgroup and smooth curve analyses. When stratified into tertiles, higher tertiles of each TyG-related index were associated with increased odds of kidney stones. TyG-WC demonstrated the strongest predictive capability for kidney stones (AUC = 0.6158), followed closely by TyG-WHtR (AUC = 0.6156) and TyG-BMI (AUC = 0.5949), with TyG showing the lowest AUC (0.5815).
This study identified significant positive associations between TyG-related indices and kidney stone formation. Among these indices, TyG-WHtR exhibited the highest predictive power for identifying kidney stone risk.
甘油三酯-葡萄糖（TyG）指数及相关指数，包括甘油三酯-葡萄糖体重指数（TyG-BMI）、甘油三酯-葡萄糖腰围（TyG-WC）和甘油三酯-葡萄糖腰高比（TyG-WHtR），越来越被认为是胰岛素抵抗（IR）的重要标志物。本研究旨在评估这些TyG相关指数与肾结石之间的关联。
这项横断面研究分析了2007年至2020年期间美国国家健康与营养检查调查（NHANES）中10824名参与者的数据。采用加权逻辑回归模型评估TyG相关指数与肾结石之间的关联，并对潜在混杂因素进行调整。进行亚组分析和平滑曲线拟合以进一步检验这些关联，同时使用受试者工作特征（ROC）曲线比较各指数的预测性能。
当将所有TyG相关指数作为连续变量分析时，均显示与肾结石存在显著正相关。TyG-BMI的比值比（OR）及95%置信区间（CI）为1.0040（1.0028，1.0052），TyG-WC为1.0015（1.0011，1.0020），TyG-WHtR为1.3305（1.2277，1.4419）。在亚组分析和平滑曲线分析中也观察到类似趋势。当分为三分位数时，各TyG相关指数的较高三分位数与肾结石发病几率增加相关。TyG-WC对肾结石的预测能力最强（AUC = 0.6158），其次是TyG-WHtR（AUC = 0.6156）和TyG-BMI（AUC = 0.5949），TyG的AUC最低（0.5815）。
本研究确定了TyG相关指数与肾结石形成之间存在显著正相关。在这些指数中，TyG-WHtR在识别肾结石风险方面具有最高的预测能力。
