一种金盐对淋巴细胞反应的影响。
Effects of a gold salt on lymphocyte responses.
作者信息
Harth M, Stiller C R, St C Sinclair N R, Evans J, McGirr D, Zuberi R
出版信息
Clin Exp Immunol. 1977 Feb;27(2):357-64.
Abstract
The effects of sodium aurothiomalate (SATM) on certain lymphocyte functions in vitro were tested. Lymphocytes were obtained from both healthy donors and patients with rheumatoid arthritis (RA). SATM depressed tritiated thymidine uptake in lymphocyte cultures stimulated by phytohaemagglutinin, and in a mixed lymphocyte response assay. Cytotoxic effector cell generation assayed by percentage specific 51Cr release was also depressed by SATM using lymphocytes from healthy donors, and from patients with RA. These effects imply that SATM inhibits both exogenous thymidine uptake, and blastogenesis, and suggest that gold salts may act in RA by interference with T-cell dependent functions.
摘要
测试了硫代苹果酸金钠（SATM）对体外某些淋巴细胞功能的影响。淋巴细胞取自健康供体和类风湿性关节炎（RA）患者。SATM抑制了在植物血凝素刺激的淋巴细胞培养物中以及混合淋巴细胞反应试验中氚标记胸腺嘧啶核苷的摄取。使用来自健康供体和RA患者的淋巴细胞，通过特异性51Cr释放百分比测定的细胞毒性效应细胞生成也被SATM抑制。这些效应表明SATM既抑制外源性胸腺嘧啶核苷摄取，也抑制细胞增殖，并提示金盐可能通过干扰T细胞依赖性功能在RA中发挥作用。
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