Termannsen Anne-Ditte, Varming Annemarie, Hansen Gitte S, Bjerre Natasja, Persson Frederik, Bagger Jonatan I, Hansen Dorte L, Ewers Bettina, Jørgensen Nils B, Blond Martin B, Hempler Nana F, Færch Kristine, Quist Jonas S
Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Herlev, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Herlev, Denmark.
J Nutr Educ Behav. 2025 Apr 29. doi: 10.1016/j.jneb.2025.03.012.
To investigate the feasibility of a 12-week time-restricted eating (TRE) intervention targeting people with overweight/obesity and complicated type 2 diabetes to inform the design of a 1-year randomized controlled trial.
In this single-arm pilot study, 20 participants with overweight/obesity and complicated type 2 diabetes were recruited from the diabetes clinics at Hvidovre Hospital and Steno Diabetes Center Copenhagen in the Greater Copenhagen area, Denmark. Participants followed 8 weeks of strict 10-hour TRE, followed by a 4-week TRE period with individual adjustments and support options.
Nineteen participants completed the intervention. Median (quartile 1-quartile 3) adherence to the eating window across all 12 weeks was 94% (86-98). Mean (95% confidence interval) reductions in body weight of -2.0 kg (-2.9 to -1.1) and hemoglobin A1c of -0.4% (-0.6 to -0.1) were observed. Participants expressed that the individualized options added flexibility to the eating concept, enabled the maintenance of social life, and eased challenging times with TRE.
Twelve weeks of TRE was feasible. Individualized adjustments and support may have the potential to facilitate the maintenance of long-term TRE.
研究针对超重/肥胖合并2型糖尿病患者进行为期12周的限时进食（TRE）干预的可行性，为一项为期1年的随机对照试验的设计提供依据。
在这项单臂试点研究中，从丹麦大哥本哈根地区的维德夫勒医院和哥本哈根斯滕诺糖尿病中心的糖尿病诊所招募了20名超重/肥胖合并2型糖尿病患者。参与者先进行8周严格的10小时限时进食，随后是为期4周的可进行个性化调整和有支持选项的限时进食期。
19名参与者完成了干预。在整个12周内，进食窗口的中位（四分位数1 - 四分位数3）依从率为94%（86 - 98）。观察到体重平均（95%置信区间）下降-2.0千克（-2.9至-1.1），糖化血红蛋白平均下降-0.4%（-0.6至-0.1）。参与者表示，个性化选项为饮食概念增加了灵活性，使社交生活得以维持，并缓解了限时进食带来挑战的时期。
为期12周的限时进食是可行的。个性化调整和支持可能有助于长期坚持限时进食。
