Solomon Matia, Bhatia R, Wang S, Blaes A H, Platz E A, Guan W, Jewett P I, Prizment A
School of Medicine, University of Minnesota, Minneapolis, MN, USA.
University of Michigan, Ann Arbor, MI, USA.
J Cancer Surviv. 2025 Apr 30. doi: 10.1007/s11764-025-01803-7.
Accelerated aging may affect quality of life (QOL), and having cancer may further complicate that relationship. We assessed the cross-sectional association of a novel proteomic aging clock (PAC) with self-reported physical and mental health and depression symptoms among individuals with and without cancer.
Data for this cross-sectional analysis came from the prospective Atherosclerosis Risk in Communities (ARIC) Study. We estimated proteomic age acceleration (PAA), i.e., the deviation of PAC from chronological age, at two ARIC visits (1990-1992 and 2011-2013). We used linear regression models to estimate the association of PAA and change in PAA with self-reported physical (PCS) and mental health (MCS) as well as depression symptoms, separately for cancer survivors and individuals without cancer.
Among cancer survivors, mean PCS, MCS, and depression scores were 44.0, 54.8, and 6.7, respectively; and 46.6, 55.3, and 6.5 among those without a cancer history. PAA was associated with lower PCS (adjusted coefficients per additional 5 years; cancer survivors, - 1.73, 95% CI - 3.11, - 0.35; without a cancer history, - 2.70, 95% CI - 3.90, - 1.51) and with higher depression scores among those without a cancer history (0.57, 95% CI 0.27, 0.88). Neither PAA nor change in PAA was associated with MCS in either population.
We found some evidence for a cross-sectional association of PAA with self-reported physical health, but little evidence for an association with mental health and depression scores.
PAA may have stronger implications for physical than for mental health outcomes among those with and without cancer.
加速衰老可能会影响生活质量（QOL），而患癌症可能会使这种关系进一步复杂化。我们评估了一种新型蛋白质组学衰老时钟（PAC）与有癌症和无癌症个体自我报告的身心健康及抑郁症状之间的横断面关联。
这项横断面分析的数据来自前瞻性社区动脉粥样硬化风险（ARIC）研究。我们在ARIC的两次随访（1990 - 1992年和2011 - 2013年）中估计了蛋白质组学年龄加速（PAA），即PAC与实际年龄的偏差。我们使用线性回归模型分别估计癌症幸存者和无癌症个体中PAA及PAA变化与自我报告的身体健康（PCS）、心理健康（MCS）以及抑郁症状之间的关联。
在癌症幸存者中，PCS、MCS和抑郁评分的平均值分别为44.0、54.8和6.7；在无癌症病史者中分别为46.6、55.3和6.5。PAA与较低的PCS相关（每增加5年的调整系数；癌症幸存者，-1.73，95%CI -3.11，-0.35；无癌症病史者，-2.70，95%CI -3.90，-1.51），且与无癌症病史者中较高的抑郁评分相关（0.57，95%CI 0.27，0.88）。在这两个人群中，PAA及PAA变化均与MCS无关。
我们发现了一些PAA与自我报告的身体健康之间存在横断面关联的证据，但与心理健康和抑郁评分之间存在关联的证据很少。
PAA对有癌症和无癌症个体的身体健康影响可能比对心理健康结果的影响更强。
