新型抗肿瘤抗生素FR-900405和FR-900406。II. 生产、分离、表征及抗肿瘤活性
New antitumor antibiotics, FR-900405 and FR-900406. II. Production, isolation, characterization and antitumor activity.
作者信息
Kiyoto S, Nishikawa M, Terano H, Kohsaka M, Aoki H, Imanaka H, Kawai Y, Uchida I, Hashimoto M
出版信息
J Antibiot (Tokyo). 1985 Jul;38(7):840-8. doi: 10.7164/antibiotics.38.840.
PMID:4030499
Abstract
The new antitumor antibiotics, FR-900405 and FR-900406, were isolated from the culture broth of Actinomadura pulveracea sp. nov. No. 6049. These compounds which contain sulfur in the molecule, represent a novel class of antitumor agents. FR-900405 and FR-900406 are highly active in mice against experimental tumors and exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi.
摘要
新型抗肿瘤抗生素FR-900405和FR-900406是从新种粉状马杜拉放线菌6049号菌株的培养液中分离得到的。这些分子中含硫的化合物代表了一类新型抗肿瘤药物。FR-900405和FR-900406在小鼠体内对实验性肿瘤具有高活性，并且对革兰氏阳性菌、革兰氏阴性菌和真菌均表现出抗菌活性。
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