Kiyoto S, Nishikawa M, Terano H, Kohsaka M, Aoki H, Imanaka H, Kawai Y, Uchida I, Hashimoto M
J Antibiot (Tokyo). 1985 Jul;38(7):840-8. doi: 10.7164/antibiotics.38.840.
The new antitumor antibiotics, FR-900405 and FR-900406, were isolated from the culture broth of Actinomadura pulveracea sp. nov. No. 6049. These compounds which contain sulfur in the molecule, represent a novel class of antitumor agents. FR-900405 and FR-900406 are highly active in mice against experimental tumors and exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi.
新型抗肿瘤抗生素FR-900405和FR-900406是从新种粉状马杜拉放线菌6049号菌株的培养液中分离得到的。这些分子中含硫的化合物代表了一类新型抗肿瘤药物。FR-900405和FR-900406在小鼠体内对实验性肿瘤具有高活性，并且对革兰氏阳性菌、革兰氏阴性菌和真菌均表现出抗菌活性。
