Kim Min Sun, Gu Seonhye, Kim Sun-Hyung, Lee Ki Man, Yang Bumhee, Lee Hyun
Division of Cardiology, Department of Internal Medicine, Biochemical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
Department of Epidemiology and Health Informatics, Korea University, Seoul, Korea.
Korean Circ J. 2025 Jul;55(7):626-636. doi: 10.4070/kcj.2024.0316. Epub 2025 Mar 18.
The development of atherosclerotic cardiovascular disease (ASCVD) in middle-aged working groups can be a major contributor to disability-adjusted life years. However, information regarding the current trends in influenza vaccination within this demographic group remains scarce. Thus, we aimed to investigate the recent 11-year trends in influenza vaccination and related factors among these populations in Korea.
Of 42,879 individuals aged 40-64 years enrolled in the Korea National Health and Nutrition Examination Survey between 2010 and 2021, 35,323 were included. We investigated the yearly trend of influenza vaccination rate according to ASCVD risk and factors associated with being unvaccinated in the elevated ASCVD risk group (ASCVD risk score: ≥7.5%).
Among the 35,323 participants, 20,392 (57.7%) were classified into the elevated ASCVD risk group. Over the 11 years, the vaccination rate was significantly higher in the elevated ASCVD risk group than in the low ASCVD risk group (33.8% vs. 25.3%, p<0.001). Factors associated with the unvaccinated status in the elevated ASCVD risk group included younger age (<50 years; adjusted odds ratio, 1.61; 95% confidence interval, 1.31-1.98), male sex (1.43; 1.16-1.76), current smoker status (1.41; 1.13-1.76), residence in an urban area (1.19; 1.01-1.41), and having higher education (1.3; 1.04-1.64).
One in 3 middle-aged working adults with an elevated risk of ASCVD received the influenza vaccination. Although the influenza vaccination rate was higher in participants with an elevated ASCVD risk than in those with low ASCVD risk, the vaccination rate was relatively unsatisfactory.
中年工作人群中动脉粥样硬化性心血管疾病（ASCVD）的发展可能是导致伤残调整生命年的主要因素。然而，关于这一人群目前流感疫苗接种趋势的信息仍然匮乏。因此，我们旨在调查韩国这些人群中最近11年的流感疫苗接种趋势及相关因素。
在2010年至2021年参加韩国国民健康与营养检查调查的42879名40 - 64岁个体中，纳入了35323名。我们根据ASCVD风险以及ASCVD风险升高组（ASCVD风险评分：≥7.5%）中未接种疫苗的相关因素，调查了流感疫苗接种率的年度趋势。
在35323名参与者中，20392名（57.7%）被归类为ASCVD风险升高组。在这11年中，ASCVD风险升高组的疫苗接种率显著高于低ASCVD风险组（33.8%对25.3%，p<0.001）。ASCVD风险升高组中与未接种状态相关的因素包括年龄较小（<50岁；调整后的优势比，1.61；95%置信区间，1.31 - 1.98）、男性（1.43；1.16 - 1.76）、当前吸烟者状态（1.41；1.13 - 1.76）、居住在城市地区（1.19；1.01 - 1.41）以及受过高等教育（1.3；1.04 - 1.64）。
三分之一ASCVD风险升高的中年在职成年人接种了流感疫苗。尽管ASCVD风险升高的参与者的流感疫苗接种率高于ASCVD风险低的参与者，但疫苗接种率相对不尽人意。
