Simngam Natchanon, Pinyopornpanish Kanokporn, Kulkheereerattana Theerach, Chuaiad Kittat, Arayakulsakol Panuwat, Pinyopornpanish Kanokwan
Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Global Health and Chronic Conditions Research Group, Chiang Mai University, Chiang Mai, 50200, Thailand.
Sci Rep. 2025 Apr 30;15(1):15250. doi: 10.1038/s41598-025-00097-0.
This study aimed to report findings from EGD investigations in older adults with dyspepsia and identify factors associated with organic dyspepsia in this population. We conducted a retrospective cross-sectional study at a tertiary care center in Northern Thailand. Medical records of adults aged 50 years and older presenting with dyspepsia who underwent initial EGD between January 2018 and December 2022 were reviewed. Organic dyspepsia includes erosive esophagitis, ulcer, mass, and cancerous lesions. Multivariable logistic regression was used to identify factors associated with organic dyspepsia. Data from 466 patients were analyzed. Functional dyspepsia was the predominant diagnosis (94.0%), while organic dyspepsia was diagnosed in 6.0% of patients. Gastric/duodenal ulcer, erosive esophagitis, and gastric malignancy accounted for 1.9%, 1.7%, and 1.1% of cases, respectively. After adjustment for covariates, a low body mass index (BMI of less than 18.5 kg/m) and male gender significantly increased the likelihood of organic dyspepsia, with an adjusted odds ratio (OR) of 4.34; 95% CI 1.45-12.09, p=0.009 and adjusted OR of 2.64; 95% CI 1.13-6.17, p=0.024, respectively. There were no significant associations found between other factors and organic dyspepsia, including age, smoking, alcohol use, symptom duration, H. pylori infection, and NSAID use.
本研究旨在报告对患有消化不良的老年人进行上消化道内镜检查（EGD）的结果，并确定该人群中与器质性消化不良相关的因素。我们在泰国北部的一家三级医疗中心进行了一项回顾性横断面研究。对2018年1月至2022年12月期间因消化不良接受初次EGD检查的50岁及以上成年人的病历进行了回顾。器质性消化不良包括糜烂性食管炎、溃疡、肿物和癌性病变。采用多变量逻辑回归分析来确定与器质性消化不良相关的因素。对466例患者的数据进行了分析。功能性消化不良是主要诊断（94.0%），而6.0%的患者被诊断为器质性消化不良。胃溃疡/十二指肠溃疡、糜烂性食管炎和胃恶性肿瘤分别占病例的1.9%、1.7%和1.1%。在对协变量进行调整后，低体重指数（体重指数小于18.5kg/m²）和男性性别显著增加了器质性消化不良的可能性，调整后的优势比（OR）分别为4.34；95%置信区间1.45 - 12.09，p = 0.009和调整后的OR为2.64；95%置信区间1.13 - 6.17，p = 0.024。未发现其他因素与器质性消化不良之间存在显著关联，包括年龄、吸烟、饮酒、症状持续时间、幽门螺杆菌感染和非甾体抗炎药的使用。
