Zhang Wei, Song Jiaqi, Xian Shuyuan, Xie Sujie, Liu Yifan, Yao Yuntao, Tong Xirui, Wu Xinru, Li Yuanan, Zhang Haoyu, Lu Bingnan, Zhou Jiajie, Zhou Yibin, Xu Dayuan, Huang Runzhi, Ji Shizhao
Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai, 200433, China.
Clin Rheumatol. 2025 Apr 30. doi: 10.1007/s10067-025-07403-1.
Rheumatic disease is a kind of disease dominated by inflammatory lesions of connective tissue and abnormal immune function. It mostly belongs to autoimmune diseases or connective tissue diseases affecting multiple organs. Meanwhile, understanding the role of RNA-binding proteins (RBPs) in pathogenesis is rapidly developing. This study aims at summarizing the hotspots in rheumatology studies related to RBPs.
Scientific papers on RBPs related to rheumatology between 1982 and 2022 were gathered from the Web of Science database. The data analysis and visualization were obtained using the Bibliometrix package. Bibliometrix package was used to analyze bibliometric indicators and visualize the trends and hotspots of the research.
A total of 964 articles met the requirement. From 1982 to 2022, the USA and Anhui Medical University were the most productive country and institution, respectively, in this field. Arthritis and Rheumatism, Annals of the Rheumatic Diseases and Arthritis & Rheumatology were the top three periodicals obtained by Bradford's law. Co-word analysis divided the keywords into three clusters, focusing on diagnosis and classification of Systemic Lupus Erythematosus, pathogenesis of osteoarthritis and pathogenesis of Rheumatoid Arthritis, respectively. Trend topic analysis revealed that pathogenesis and classification of rheumatic diseases might be the research trend.
Focusing on RBPs in rheumatic diseases, we illustrated the evolution of this field and predicted future research hotspots. The research trend topics have evolved towards clinical classification and pathogenesis at the molecular and genetic level. The pathogenic mechanism in rheumatic diseases will continue to be a hotspot in the future. Besides, the classification of Systemic Lupus Erythematosus patients may be another hotspot. Researchers are recommended to pay more attention to hotspots demonstrated in the future. Key Points • Bibliometrix package was used to analyze bibliometric indicators and visualize the trends and hotspots of the research. • Focusing on RBPs in rheumatic diseases, we illustrated the evolution of this field and predicted future research hotspots. • The research trend topics have evolved towards clinical classification and the pathogenesis at the molecular and genetic level. • The pathogenic mechanism in rheumatic diseases will continue to be a hotspot in the future.
风湿性疾病是一类以结缔组织炎症性病变和免疫功能异常为主的疾病。它大多属于自身免疫性疾病或累及多器官的结缔组织疾病。同时，关于RNA结合蛋白（RBPs）在发病机制中的作用的研究正在迅速发展。本研究旨在总结与RBPs相关的风湿病学研究热点。
从Web of Science数据库收集了1982年至2022年期间与风湿病学相关的关于RBPs的科学论文。使用Bibliometrix软件包进行数据分析和可视化。Bibliometrix软件包用于分析文献计量指标并可视化研究趋势和热点。
共有964篇文章符合要求。从1982年到2022年，美国和安徽医科大学分别是该领域产出最多的国家和机构。根据布拉德福定律，《关节炎与风湿病》《风湿病学年鉴》和《关节炎与风湿病学》是排名前三的期刊。共词分析将关键词分为三个聚类，分别聚焦于系统性红斑狼疮的诊断和分类、骨关节炎的发病机制以及类风湿关节炎的发病机制。趋势主题分析显示，风湿病的发病机制和分类可能是研究趋势。
聚焦于风湿性疾病中的RBPs，我们阐述了该领域的发展历程并预测了未来的研究热点。研究趋势主题已朝着临床分类以及分子和基因水平的发病机制发展。风湿性疾病的发病机制在未来仍将是一个热点。此外，系统性红斑狼疮患者的分类可能是另一个热点。建议研究人员更多地关注未来展现出的热点。要点 • 使用Bibliometrix软件包分析文献计量指标并可视化研究趋势和热点。 • 聚焦于风湿性疾病中的RBPs，我们阐述了该领域的发展历程并预测了未来的研究热点。 • 研究趋势主题已朝着临床分类以及分子和基因水平的发病机制发展。 • 风湿性疾病的发病机制在未来仍将是一个热点。
