Rabbani Mina, Sanjari Mostafa Soltan, Sadeghi Ali, Neshastesaz Hanieh, Rabbani Zahra, Khiabani Salar
School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Eye Research Center, Eye Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
BMC Ophthalmol. 2025 Apr 30;25(1):264. doi: 10.1186/s12886-025-04099-4.
Previous studies have provided evidence that non-arterial ischemic optic neuropathy (NAION), vitreous traction, and posterior vitreous detachment (PVD) may be related; However, a detailed description of the predictive features of PVD in these patients has been provided in a few studies so far. By conducting this study, we decided to take a positive step in clarifying the pathophysiology of the relationship between the two disorders and increasing the patient's quality of life through early detection.
In this descriptive cross-sectional study, after obtaining the necessary permits from the Ethics Committee of Iran University of Medical Sciences, the information in the clinical records of patients with ischemic optic neuropathy referred to Rasoul Akram Hospital from March 2022 to December 2023 was analyzed. Exclusion criteria included having diabetes, intraocular bleeding, intraocular inflammation, and a history of eye trauma or surgery. Moreover, patient information including age, gender, presence of papillary edema, optic atrophy, intracranial pressure (ICP) rise, and presence of PVD was extracted from the file. At the end, the data collected from the patients was entered into the statistical software SPSS version 26 and employed Chi-square tests for analysis.
PVD was seen in 18 patients (18.9%) out of 95 patients evaluated. A statistically significant relationship was seen only between the age group of patients with the presence of PVD (P = 0.028); In this way, with increasing age, the percentage of PVD from 0.0% in the age group below 18 years, to 7.1% in the age group 18-38 years, to 26.2% in the age group 38-58 years and to 7. 35% was significantly increased in the age group of 58 years respectively. Meanwhile, no statistically significant relationship was found between other variables including gender, the presence of papillary edema, optic atrophy, and ICP rise with the presence of PVD (P > 0.05).
In patients with optic nerve ischemic neuropathy, the incidence of PVD increases significantly with age. Therefore, to find a causal relationship between PVD and optic nerve ischemic neuropathy, an age-related factor should be sought. Hence, future research should be designed and implemented to compare the mechanism of PVD and non-arteritic ischemic optic neuropathy (NAION) at the same time in different age groups.
以往研究已提供证据表明非动脉性缺血性视神经病变（NAION）、玻璃体牵拉和玻璃体后脱离（PVD）可能相关；然而，目前仅有少数研究对这些患者中PVD的预测特征进行了详细描述。通过开展本研究，我们决定朝着阐明这两种疾病之间关系的病理生理学，并通过早期检测提高患者生活质量迈出积极的一步。
在这项描述性横断面研究中，在获得伊朗医科大学伦理委员会的必要许可后，对2022年3月至2023年12月转诊至拉苏勒·阿克拉姆医院的缺血性视神经病变患者临床记录中的信息进行了分析。排除标准包括患有糖尿病、眼内出血、眼内炎症以及有眼外伤或手术史。此外，从病历中提取患者信息，包括年龄、性别、是否存在视乳头水肿、视神经萎缩、颅内压（ICP）升高以及是否存在PVD。最后，将从患者收集的数据录入统计软件SPSS 26版，并采用卡方检验进行分析。
在95例接受评估的患者中，有18例（18.9%）出现了PVD。仅在存在PVD的患者年龄组之间存在统计学显著关系（P = 0.028）；具体而言，随着年龄增长，PVD的百分比从18岁以下年龄组的0.0%，增至18 - 38岁年龄组的7.1%，再增至38 - 58岁年龄组的26.2%，在58岁及以上年龄组显著增至73.5%。同时，在包括性别、视乳头水肿、视神经萎缩以及ICP升高与PVD存在情况等其他变量之间未发现统计学显著关系（P > 0.05）。
在视神经缺血性神经病变患者中，PVD的发生率随年龄显著增加。因此，为了找出PVD与视神经缺血性神经病变之间的因果关系，应探寻与年龄相关的因素。因此，未来的研究应设计并实施，以同时比较不同年龄组中PVD和非动脉性缺血性视神经病变（NAION）的机制。
