Ernest Deepali K, Collier Asha, Chandrasekhar Aparajita, Xie Luyu, Darraji Shaghayegh, Patel Jenil, Almandoz Jaime P, Messiah Sarah E
Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
School of Human Ecology, University of Texas at Austin, Austin, Texas, USA.
Womens Health Rep (New Rochelle). 2025 Apr 14;6(1):431-441. doi: 10.1089/whr.2024.0143. eCollection 2025.
Polycystic ovarian syndrome (PCOS) is associated with the metabolic health of racially and ethnically diverse women globally, but limited research exists on the association of PCOS and metabolic syndrome (MetS) among women in the United States.
To examine the association of PCOS features and MetS in a racially/ethnically diverse population of reproductive-aged women in the United States.
Cross-sectional data from 2,172 women (12-49 years) from the 2011-2016 National Health and Nutrition Examination Survey were analyzed. Univariate logistic regression models determined unadjusted associations of MetS and its components (elevated central obesity, glucose, blood pressure and triglyceride, and low high-density lipoprotein cholesterol) with PCOS features (log-transformed total testosterone (LTT), sex-hormone binding globulin (LSHBG), amenorrhea, and oral contraceptive pills (OCP) use). Multivariable logistic models examined age-adjusted associations stratified by race and ethnicity.
The analytical sample (mean age = 30.3 years, 59% non-Hispanic White, 12.4% non-Hispanic Black, 18.7% Hispanic/Latina, 6.2% non-Hispanic Asian, 3.7% Other/multi-race) had a MetS prevalence of 14.5%. Overall, MetS was associated with age, body mass index, race/ethnicity, LTT and LSHBG concentrations, amenorrhea, and OCP use ( < 0.01 for all), and many of the PCOS features were protective against individual MetS components. Most race/ethnicities showed significantly lower odds of MetS with an increase in LSHBG, with varying impacts on individual MetS features.
Findings suggest significant associations between PCOS features and MetS among a racially and ethnically diverse population of reproductive-aged women in the United States. More robust and longitudinal studies are needed to further understand the underlying mechanism linking PCOS and MetS.
多囊卵巢综合征（PCOS）与全球不同种族和民族女性的代谢健康相关，但在美国女性中，关于PCOS与代谢综合征（MetS）关联的研究有限。
在美国不同种族/民族的育龄女性人群中，研究PCOS特征与MetS之间的关联。
分析了2011 - 2016年美国国家健康与营养检查调查中2172名年龄在12 - 49岁女性的横断面数据。单因素逻辑回归模型确定了MetS及其组分（中心性肥胖、血糖、血压和甘油三酯升高，以及高密度脂蛋白胆固醇降低）与PCOS特征（对数转换后的总睾酮（LTT）、性激素结合球蛋白（LSHBG）、闭经和口服避孕药（OCP）使用）之间的未调整关联。多变量逻辑模型检验了按种族和民族分层的年龄调整后的关联。
分析样本（平均年龄 = 30.3岁，59%为非西班牙裔白人，12.4%为非西班牙裔黑人，18.7%为西班牙裔/拉丁裔，6.2%为非西班牙裔亚洲人，3.7%为其他/多种族）的MetS患病率为14.5%。总体而言，MetS与年龄、体重指数、种族/民族、LTT和LSHBG浓度、闭经及OCP使用均相关（所有P < 0.01），且许多PCOS特征对个体MetS组分具有保护作用。大多数种族/民族显示，随着LSHBG升高，MetS的几率显著降低，对个体MetS特征的影响各不相同。
研究结果表明，在美国不同种族和民族的育龄女性人群中，PCOS特征与MetS之间存在显著关联。需要更有力的纵向研究来进一步了解PCOS与MetS之间潜在的联系机制。
