Carbonell Juan D, Fernández Nélida, Escobar Manuel J, Álvarez Maria T, Sánchez Lucia, Hernández Aday, Meana Aránzazu
Department of Animal Health, Faculty of Veterinary, Complutense University of Madrid, Madrid, Spain.
Faculty of Veterinary, University Alfonso X El Sabio, Madrid, Spain.
J Parasitol Res. 2025 Apr 22;2025:8948099. doi: 10.1155/japr/8948099. eCollection 2025.
Chorioptic mange is a challenging condition to treat due to the superficial locations of the nonhematophagous mite , and while topical acaricides are recommended, the clinical feature relapses are frequent. In a double-blinded clinical trial, three randomized groups of Spanish-Breton horses ( = 32) naturally infected with on their legs were evaluated over a period of 70 days. All treatments were applied once every 14 days for three treatments. Before treatment and on Day (D)10, D25, D37, D56, and D70, each leg per animal was scored according to equine pastern dermatitis clinical presentations and severity (1 = mild, 2 = exudative, and 3 = chronic proliferative), and mite reduction was calculated using a 2 × 6 adhesive tape counting total mites on D36, D56, and D70. The trial aimed to assess the clinical improvement and efficacy of a topical pyrethroid emulsion alone (Group 1), and in combination with benzoyl peroxide (Group 2), compared to a control group (Group 3). The trial also included environmental disinfection. The acaricide efficacy was determined using Abbott's formula. Our analysis reveals no adverse reactions attributable to the treatment, yet lesions showed limited clinical improvement. Both treatment groups exhibited mite reduction compared to the control. The mite reduction on the evaluated days was 14.58%, 47.62%, and 55.77% for Group 1 and 85.42%, 88.10%, and 78.85% for Group 2, respectively. The mite reduction was significant in Group 2 on D56 and D70 ( < 0.0156) compared to the pretreatment and superior to Group 1 ( < 0.0229) at the end of the study (D70). The age and mite numbers showed no significant connection. In horses with higher clinical scores, there were no significant changes, most probably due to the short length of the study. The combination of benzoyl peroxide with topical pyrethroids can reduce the numbers of mites, and it can be considered an alternative therapeutic option in horses.
由于非吸血螨寄生于体表浅层，绒毛虱螨病是一种难以治疗的疾病。虽然推荐使用局部杀螨剂，但临床症状频繁复发。在一项双盲临床试验中，对三组随机分组的西班牙-布列塔尼马（n = 32）进行了为期70天的评估，这些马的腿部自然感染了[具体螨虫名称未给出]。所有治疗均每14天进行一次，共进行三次治疗。在治疗前以及第10天、第25天、第37天、第56天和第70天，根据马蹄皮炎的临床表现和严重程度（1 = 轻度，2 = 渗出性，3 = 慢性增殖性）对每只动物的每条腿进行评分，并在第36天、第56天和第70天使用2×6的胶带计算螨虫减少量，统计总螨虫数。该试验旨在评估单独使用局部拟除虫菊酯乳液（第1组）以及与过氧化苯甲酰联合使用（第2组）相对于对照组（第3组）的临床改善情况和疗效。该试验还包括环境消毒。使用雅培公式确定杀螨剂的疗效。我们的分析显示，治疗未引起不良反应，但病变的临床改善有限。与对照组相比，两个治疗组的螨虫数量均有所减少。在评估的天数中，第1组的螨虫减少率分别为14.58%、47.62%和55.77%，第2组分别为85.42%、88.10%和78.85%。与治疗前相比，第2组在第56天和第70天的螨虫减少具有显著性（P < 0.0156），并且在研究结束时（第70天）优于第1组（P < 0.0229）。年龄和螨虫数量之间没有显著关联。在临床评分较高的马匹中，没有显著变化，这很可能是由于研究时间较短。过氧化苯甲酰与局部拟除虫菊酯联合使用可以减少[具体螨虫名称未给出]的数量，可被视为马匹的一种替代治疗选择。
Zotero 插件
